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Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-alpha,beta-DL-aspartyl-L-arginine
Gui, Lin1; Zhao, Ming1; Wang, Yuji1; Wang, Yinye2; Qin, Yang1; Li, Li1; Peng, Shiqi1
刊名MEDCHEMCOMM
2012
DOI10.1039/c1md00222h
3期:1页:102-108
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]POLYASPARTIC ACID ; CALCIUM-CARBONATE ; GROWTH-KINETICS ; AQUEOUS-MEDIA ; THIN-FILMS ; NANOPARTICLES ; THROMBOLYSIS ; DELIVERY ; CHITOSAN ; MODELS
英文摘要

In the nanoscale assembly-based design of antithrombotic agents, poly-alpha,beta-DL-aspartyl-L-arginine (MW: 20 741) was prepared. from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-arginine. In the pH environments corresponding to the stomach (pH 1.2), intestinal tract (pH 7.6), blood and tissue fluids (pH 7.4) 4.8 x 10(4,2,-4,-6,-8) nM of poly-alpha,beta-DL-aspartyl-L-arginine assembled to form diverse nano-species. The sizes of the smallest nanoparticle, nanobell and nanomango were less than 100 nm. At the oral doses of 0.72, 1.44 and 2.89 mu mol kg(-1), poly-alpha,beta-DL-aspartyl-L-arginine dose-dependently inhibited the ex vivo platelet aggregation and the in vivo thrombosis of the treated rats. By assembling to form diverse nano-species, the absorption of oral poly-alpha,beta-DL-aspartyl-L-arginine in the stomach and intestinal tract could be assisted.

语种英语
WOS记录号WOS:000299975300017
项目编号KM200910025-009 ; 2011ZX09302-007-01 ; 81072522 ; 21103115
资助机构PHR (IHLB) ; Special Project ; Natural Scientific Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65816
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gui, Lin,Zhao, Ming,Wang, Yuji,et al. Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-alpha,beta-DL-aspartyl-L-arginine[J]. MEDCHEMCOMM,2012,3(1):102-108.
APA Gui, Lin.,Zhao, Ming.,Wang, Yuji.,Wang, Yinye.,Qin, Yang.,...&Peng, Shiqi.(2012).Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-alpha,beta-DL-aspartyl-L-arginine.MEDCHEMCOMM,3(1),102-108.
MLA Gui, Lin,et al."Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-alpha,beta-DL-aspartyl-L-arginine".MEDCHEMCOMM 3.1(2012):102-108.
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