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学科主题: 药学
题名:
Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-alpha,beta-DL-aspartyl-L-arginine
作者: Gui, Lin1; Zhao, Ming1; Wang, Yuji1; Wang, Yinye2; Qin, Yang1; Li, Li1; Peng, Shiqi1
刊名: MEDCHEMCOMM
发表日期: 2012
DOI: 10.1039/c1md00222h
卷: 3, 期:1, 页:102-108
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: POLYASPARTIC ACID ; CALCIUM-CARBONATE ; GROWTH-KINETICS ; AQUEOUS-MEDIA ; THIN-FILMS ; NANOPARTICLES ; THROMBOLYSIS ; DELIVERY ; CHITOSAN ; MODELS
英文摘要:

In the nanoscale assembly-based design of antithrombotic agents, poly-alpha,beta-DL-aspartyl-L-arginine (MW: 20 741) was prepared. from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-arginine. In the pH environments corresponding to the stomach (pH 1.2), intestinal tract (pH 7.6), blood and tissue fluids (pH 7.4) 4.8 x 10(4,2,-4,-6,-8) nM of poly-alpha,beta-DL-aspartyl-L-arginine assembled to form diverse nano-species. The sizes of the smallest nanoparticle, nanobell and nanomango were less than 100 nm. At the oral doses of 0.72, 1.44 and 2.89 mu mol kg(-1), poly-alpha,beta-DL-aspartyl-L-arginine dose-dependently inhibited the ex vivo platelet aggregation and the in vivo thrombosis of the treated rats. By assembling to form diverse nano-species, the absorption of oral poly-alpha,beta-DL-aspartyl-L-arginine in the stomach and intestinal tract could be assisted.

语种: 英语
所属项目编号: KM200910025-009 ; 2011ZX09302-007-01 ; 81072522 ; 21103115
项目资助者: PHR (IHLB) ; Special Project ; Natural Scientific Foundation of China
WOS记录号: WOS:000299975300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65816
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Gui, Lin,Zhao, Ming,Wang, Yuji,et al. Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-alpha,beta-DL-aspartyl-L-arginine[J]. MEDCHEMCOMM,2012,3(1):102-108.
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