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学科主题: 临床医学
题名:
Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma
作者: Gong, Kan; Zhang, Ning; Zhang, Zheng; Na, Yanqun
关键词: sporadic renal cell carcinoma ; pathogenesis ; Epo ; EpoR ; VHL mutation
刊名: CANCER BIOLOGY & THERAPY
发表日期: 2006-06-01
卷: 5, 期:6, 页:582-585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HIPPEL-LINDAU-DISEASE ; ERYTHROPOIETIN ; CANCER ; GENE ; PROLIFERATION
英文摘要:

Clear cell renal cell carcinoma (CCRCC) is the most common renal carcinoma and it is often associated with von Hippel-Lindau disease (VHL) gene mutations. CCRCCs with VHL mutations demonstrate hypoxia-inducible factor (HIF) overexpression as well as increased expression of vascular endothelial growth factor ( VEGF). Recently, the erythropoietin (Epo) has been found to be upregulated in renal and other tumors associated with VHL disease. Furthermore, Epo and Epo receptor (EpoR) coexpression has also been reported in these tumors. The results provided strong evidence that an autocrine loop is involved in tumorigenesis in VHL disease. We investigated whether Epo and EpoR coexpression also occurs in sporadic CCRCC. Fifty-four sporadic CCRCCs were analyzed. VHL gene mutations were detected in 30 out of 54 tumors. Coexpression of Epo and EpoR was detected in 50 out of 54 tumors regardless of their VHL mutation status. The results suggest that coexpression of Epo and EpoR plays an important role in tumorigenesis of sporadic CCRCC.

语种: 英语
WOS记录号: WOS:000239909500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65819
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Inst Urol, Dept Urol, Beijing 100034, Peoples R China
2.Capital Univ Med Sci, Bei Jing Chao Yang Hosp, Dept Urol, Beijing, Peoples R China

Recommended Citation:
Gong, Kan,Zhang, Ning,Zhang, Zheng,et al. Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma[J]. CANCER BIOLOGY & THERAPY,2006,5(6):582-585.
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