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学科主题临床医学
Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma
Gong, Kan; Zhang, Ning; Zhang, Zheng; Na, Yanqun
关键词sporadic renal cell carcinoma pathogenesis Epo EpoR VHL mutation
刊名CANCER BIOLOGY & THERAPY
2006-06-01
5期:6页:582-585
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HIPPEL-LINDAU-DISEASE ; ERYTHROPOIETIN ; CANCER ; GENE ; PROLIFERATION
英文摘要

Clear cell renal cell carcinoma (CCRCC) is the most common renal carcinoma and it is often associated with von Hippel-Lindau disease (VHL) gene mutations. CCRCCs with VHL mutations demonstrate hypoxia-inducible factor (HIF) overexpression as well as increased expression of vascular endothelial growth factor ( VEGF). Recently, the erythropoietin (Epo) has been found to be upregulated in renal and other tumors associated with VHL disease. Furthermore, Epo and Epo receptor (EpoR) coexpression has also been reported in these tumors. The results provided strong evidence that an autocrine loop is involved in tumorigenesis in VHL disease. We investigated whether Epo and EpoR coexpression also occurs in sporadic CCRCC. Fifty-four sporadic CCRCCs were analyzed. VHL gene mutations were detected in 30 out of 54 tumors. Coexpression of Epo and EpoR was detected in 50 out of 54 tumors regardless of their VHL mutation status. The results suggest that coexpression of Epo and EpoR plays an important role in tumorigenesis of sporadic CCRCC.

语种英语
WOS记录号WOS:000239909500014
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65819
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Peking Univ Hosp 1, Inst Urol, Dept Urol, Beijing 100034, Peoples R China
2.Capital Univ Med Sci, Bei Jing Chao Yang Hosp, Dept Urol, Beijing, Peoples R China
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GB/T 7714
Gong, Kan,Zhang, Ning,Zhang, Zheng,et al. Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma[J]. CANCER BIOLOGY & THERAPY,2006,5(6):582-585.
APA Gong, Kan,Zhang, Ning,Zhang, Zheng,&Na, Yanqun.(2006).Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma.CANCER BIOLOGY & THERAPY,5(6),582-585.
MLA Gong, Kan,et al."Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma".CANCER BIOLOGY & THERAPY 5.6(2006):582-585.
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