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In vitro phosphate-binding ability of calcium-based agents is augmented by co-administration of activated charcoal
Jia, Meng1,2,3; Cheng, Xu-yang1,2,3; Zuo, Li1,2,3
关键词activated charcoal hyperphosphatemia phosphate binder chronic kidney disease end-stage renal disease
刊名CLINICAL NEPHROLOGY
2013-06-01
DOI10.5414/CN107713
79期:6页:471-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]HEMODIALYSIS ; CARBONATE
英文摘要

Background: Calcium carbonate is widely used as a phosphate binder in patients on maintenance hemodialysis. An unwanted side effect of calcium carbonate is hypercalcemia and vascular calcification. Oral activated charcoal (AC) is a non-selective and highly effeotive adsorbent. We hypothesized that AC augments the phosphate binding capacity of calcium-based agents. We performed an in vitro study to test this hypothesis. Methods: Simulated gastric fluid and intestinal fluid were prepared with a phosphate concentration of 10 mmol/l. Different dosages of calcium chloride (0.083 g, 0.167 g, and 0.250 g), AC (0.15 g, 0.30 g, and 0.45 g) or a combination of both were added to either gastric or intestinal fluid for phosphate binding. After a reaction time of 2 hours, phosphate concentrations in the supernatant were measured, and absolute reduction and percent reduction of phosphate were calculated. The phosphate-binding abilities of calcium chloride, AC, and a combination of both were compared. Results: In simulated intestinal fluid there was no significant difference in the percent reduction of phosphate concentrations among the different calcium chloride concentration groups (28.90 +/- 2.04 vs. 33.33 +/- 3.90 vs. 31.86 +/- 5.23) and there was still no significant difference in phosphate concentrations among the different AC groups (3.33 +/- 0.08 vs. 3.26 +/- 0.01 vs. 3.36 +/- 0.11). In simulated gastric fluid phosphate concentrations at each of the time points (before the reaction, 1 hour after calcium chloride was added, and 2 hours after AC was added) were not significantly different. In simulated intestinal fluid the percent decrease in phosphate concentration in the calcium chloride + AC group was significantly higher than that in the calcium chloride group (48.23 +/- 5.55 vs. 30.72 +/- 6.11). Conclusions: AC alone had no phosphate-binding ability in either gastric or intestinal fluid. The phosphate-binding ability of calcium chloride was improved by AC in intestinal fluid.

语种英语
WOS记录号WOS:000320840400007
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65821
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
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Jia, Meng,Cheng, Xu-yang,Zuo, Li. In vitro phosphate-binding ability of calcium-based agents is augmented by co-administration of activated charcoal[J]. CLINICAL NEPHROLOGY,2013,79(6):471-476.
APA Jia, Meng,Cheng, Xu-yang,&Zuo, Li.(2013).In vitro phosphate-binding ability of calcium-based agents is augmented by co-administration of activated charcoal.CLINICAL NEPHROLOGY,79(6),471-476.
MLA Jia, Meng,et al."In vitro phosphate-binding ability of calcium-based agents is augmented by co-administration of activated charcoal".CLINICAL NEPHROLOGY 79.6(2013):471-476.
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