|Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women|
|Zheng, Liyuan1; Song, Aiping1; Ruan, Yuan1; Chen, Lan2; Liu, Dongge2; Li, Xianghong3; Guo, Hongyan4; Han, Jiyuan1; Li, Yan1; Tian, Xinxia1; Fang, Weigang1|
|关键词||Single nucleotide polymorphism (SNP) Ovarian cancer AURKA BRCA1 CCNE1 CDK2|
|WOS标题词||Science & Technology|
|类目[WOS]||Oncology ; Public, Environmental & Occupational Health|
|研究领域[WOS]||Oncology ; Public, Environmental & Occupational Health|
|关键词[WOS]||SINGLE-NUCLEOTIDE POLYMORPHISMS ; SPORADIC BREAST-CANCER ; CENTROSOME AMPLIFICATION ; BRCA1-DEPENDENT UBIQUITINATION ; COMMON VARIANTS ; CANDIDATE GENE ; CELL-DIVISION ; CYCLIN-E ; RISK ; HAPLOTYPE|
Introduction: Centrosome aberrations and cell-cycle deregulation have important implications for ovarian cancer development. The AURKA, BRCA1, CCNE1 and CDK2 genes play pivotal roles in centrosome duplication and cell-cycle regulation.
Methods: Using a haplotype-based analysis, this study aimed to investigate whether genetic polymorphisms in these four genes may contribute to ovarian cancer susceptibility. A total of 22 single nucleotide polymorphisms (SNPs) in these four genes were genotyped in 287 cases of ovarian serous cystadenocarcinomas and 618 age-matched cancer-free controls from the Chinese Han population, and then haplotype blocks were reconstructed according to our genotyping data and linkage disequilibrium (LD) status of these SNPs.
Results: For AURKA, we found that haplotype GA [rs6064391 (T -> G) + rs911162 (G -> A)] was strongly associated with decreased ovarian cancer risk (adjusted OR = 0.31, 95% CI = 0.15-0.63, P = 0.0012). For BRCA1, we found that haplotype CGTAG was associated with decreased ovarian cancer risk (adjusted OR = 0.64, 95% CI = 0.41-0.98, P = 0.0417). Moreover, women harboring homozygous GA/CGTAG haplotypes showed the lowest risk (OR = 0.12, 95% CI = 0.02-0.94, P = 0.0438). In CCNE1, the SNPs rs3218035 and rs3218042 were significantly associated with increased ovarian cancer risk (rs3218035: adjusted OR = 5.20, 95% CI = 1.85-14.52, P = 0.0017; rs3218042: adjusted OR = 4.98, 95% CI = 1.75-14.19, P = 0.0027). For CDK2, no significant association was found.
Conclusions: This study indicates that genetic polymorphisms of AURKA, BRCA1 and CCNE1 may affect ovarian cancer susceptibility in Chinese Han women. (C) 2013 Elsevier Ltd. All rights reserved.
|项目编号||81171961 ; 20110001110060|
|资助机构||National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education of China|
|作者单位||1.Beijing Hosp, Dept Pathol, Beijing, Peoples R China|
2.Peking Univ, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Hlth Sci Ctr,Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100191, Peoples R China
4.Peking Univ, Dept Gynecol, Hosp 3, Beijing 100191, Peoples R China
|Zheng, Liyuan,Song, Aiping,Ruan, Yuan,et al. Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women[J]. CANCER EPIDEMIOLOGY,2013,37(5):639-646.|
|APA||Zheng, Liyuan.,Song, Aiping.,Ruan, Yuan.,Chen, Lan.,Liu, Dongge.,...&Fang, Weigang.(2013).Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women.CANCER EPIDEMIOLOGY,37(5),639-646.|
|MLA||Zheng, Liyuan,et al."Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women".CANCER EPIDEMIOLOGY 37.5(2013):639-646.|
|Genetic polymorphism（672KB）||期刊论文||出版稿||开放获取||CC BY-NC-SA||浏览 请求全文|