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学科主题: 基础医学
题名:
Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women
作者: Zheng, Liyuan1; Song, Aiping1; Ruan, Yuan1; Chen, Lan2; Liu, Dongge2; Li, Xianghong3; Guo, Hongyan4; Han, Jiyuan1; Li, Yan1; Tian, Xinxia1; Fang, Weigang1
关键词: Single nucleotide polymorphism (SNP) ; Ovarian cancer ; AURKA ; BRCA1 ; CCNE1 ; CDK2
刊名: CANCER EPIDEMIOLOGY
发表日期: 2013-10-01
DOI: 10.1016/j.canep.2013.04.018
卷: 37, 期:5, 页:639-646
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: SINGLE-NUCLEOTIDE POLYMORPHISMS ; SPORADIC BREAST-CANCER ; CENTROSOME AMPLIFICATION ; BRCA1-DEPENDENT UBIQUITINATION ; COMMON VARIANTS ; CANDIDATE GENE ; CELL-DIVISION ; CYCLIN-E ; RISK ; HAPLOTYPE
英文摘要:

Introduction: Centrosome aberrations and cell-cycle deregulation have important implications for ovarian cancer development. The AURKA, BRCA1, CCNE1 and CDK2 genes play pivotal roles in centrosome duplication and cell-cycle regulation.

Methods: Using a haplotype-based analysis, this study aimed to investigate whether genetic polymorphisms in these four genes may contribute to ovarian cancer susceptibility. A total of 22 single nucleotide polymorphisms (SNPs) in these four genes were genotyped in 287 cases of ovarian serous cystadenocarcinomas and 618 age-matched cancer-free controls from the Chinese Han population, and then haplotype blocks were reconstructed according to our genotyping data and linkage disequilibrium (LD) status of these SNPs.

Results: For AURKA, we found that haplotype GA [rs6064391 (T -> G) + rs911162 (G -> A)] was strongly associated with decreased ovarian cancer risk (adjusted OR = 0.31, 95% CI = 0.15-0.63, P = 0.0012). For BRCA1, we found that haplotype CGTAG was associated with decreased ovarian cancer risk (adjusted OR = 0.64, 95% CI = 0.41-0.98, P = 0.0417). Moreover, women harboring homozygous GA/CGTAG haplotypes showed the lowest risk (OR = 0.12, 95% CI = 0.02-0.94, P = 0.0438). In CCNE1, the SNPs rs3218035 and rs3218042 were significantly associated with increased ovarian cancer risk (rs3218035: adjusted OR = 5.20, 95% CI = 1.85-14.52, P = 0.0017; rs3218042: adjusted OR = 4.98, 95% CI = 1.75-14.19, P = 0.0027). For CDK2, no significant association was found.

Conclusions: This study indicates that genetic polymorphisms of AURKA, BRCA1 and CCNE1 may affect ovarian cancer susceptibility in Chinese Han women. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81171961 ; 20110001110060
项目资助者: National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education of China
WOS记录号: WOS:000325369800020
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65830
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Beijing Hosp, Dept Pathol, Beijing, Peoples R China
2.Peking Univ, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Hlth Sci Ctr,Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100191, Peoples R China
4.Peking Univ, Dept Gynecol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Zheng, Liyuan,Song, Aiping,Ruan, Yuan,et al. Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women[J]. CANCER EPIDEMIOLOGY,2013,37(5):639-646.
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