IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Recent Pharmacokinetic Studies in Combination Therapies for Diabetes and Related Vascular Complications
Lu, He-Qi1; Lu, Wei2; Liu, Jun3; Yang, Kun-Jie1; Li, Zhi-Geng1
关键词Combination therapy diabetes diabetic vascular complications pharmacokinetics pharmacokinetics/pharmacodynamics population pharmacokinetics
刊名CURRENT VASCULAR PHARMACOLOGY
2015
13期:4页:554-561
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]DIPHOSPHATE RECEPTOR ANTAGONISTS ; DRUG-INTERACTIONS ; CLINICAL PHARMACOKINETICS ; IN-VITRO ; ANTIHYPERGLYCEMIC AGENTS ; REDUCTASE INHIBITORS ; PHARMACODYNAMICS ; INSULIN ; METFORMIN ; METABOLISM
英文摘要

Background: Combination treatment has been a popular therapeutic strategy in diabetes and related vascular complications. However, the reasonable dosing regimen in combination treatment remains unknown. Nowadays, pharmacokinetics (PK) is becoming a useful approach to reveal the mechanisms of drug-drug interactions (DDIs) and reasonable drug compatibility in combination treatment.

Scope: This article reviews the pharmacokinetics studies on combination therapies for diabetes and its vascular complications to reveal the mechanisms of reasonable drug compatibility for optimizing drug combination treatment.

Methods: Relevant articles were identified through the PubMed search (from January 2006 to December 2012) in English and the CNKI and Wan Wei websites in Chinese (from January 2000 to December 2012).

Findings: Thirty-six articles were identified, including 15 on DDIs, 8 on pharmacological mechanism or metabolic pathways, and 6 on non-drug factors. DDIs studies showed the changes of drug-effect in combination treatment, which could guide physicians to administer anti-hyperglycemic agent in best time and in optimal order. PK studies based on pharmacological mechanism or metabolic pathways revealed reasonable compatibility of fixed-dose combination (FDC). A combination of pharmacokinetics/pharmacodynamics (PK/PD) and population pharmacokinetics (PopPK) and the development of PK/PD models in PK studies were good ways to determine the rational use and treatment effects in combined therapies. There were other 7 PK studies on the compatibility of preparations in Chinese medicine, which also outlined the features of DDIs in herbal drugs.

Conclusion: PK studies may be useful to resolve the growing and complex issue of drug combinations to devise reasonable treatment regimens and to make physicians recognize the mechanisms of combined therapies. However, more long-term, comprehensive PK studies on combination therapy should be conducted in future.

语种英语
WOS记录号WOS:000358868200014
项目编号81102741 ; Z0214 ; YZ-1320
资助机构National Natural Science Foundation of China ; China Academy of Chinese Medical Sciences
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65838
专题北京大学药学院_药剂学系
作者单位1.China Acad Chinese Med Sci, Inst Basic Theory Tradit Chinese Med, Beijing 100700, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
推荐引用方式
GB/T 7714
Lu, He-Qi,Lu, Wei,Liu, Jun,et al. Recent Pharmacokinetic Studies in Combination Therapies for Diabetes and Related Vascular Complications[J]. CURRENT VASCULAR PHARMACOLOGY,2015,13(4):554-561.
APA Lu, He-Qi,Lu, Wei,Liu, Jun,Yang, Kun-Jie,&Li, Zhi-Geng.(2015).Recent Pharmacokinetic Studies in Combination Therapies for Diabetes and Related Vascular Complications.CURRENT VASCULAR PHARMACOLOGY,13(4),554-561.
MLA Lu, He-Qi,et al."Recent Pharmacokinetic Studies in Combination Therapies for Diabetes and Related Vascular Complications".CURRENT VASCULAR PHARMACOLOGY 13.4(2015):554-561.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lu, He-Qi]的文章
[Lu, Wei]的文章
[Liu, Jun]的文章
百度学术
百度学术中相似的文章
[Lu, He-Qi]的文章
[Lu, Wei]的文章
[Liu, Jun]的文章
必应学术
必应学术中相似的文章
[Lu, He-Qi]的文章
[Lu, Wei]的文章
[Liu, Jun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。