IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Development of the dendritic cell system during mouse ontogeny
Dakic, A; Shao, QX; D′ Amico, A; O′ Keeffe, M; Chen, WF; Shortman, K; Wu, L
刊名JOURNAL OF IMMUNOLOGY
2004-01-15
172期:2页:1018-1027
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]CD8(+) T-CELLS ; IN-VIVO ; NEWBORN MICE ; STEADY-STATE ; FLT3 LIGAND ; IFN-GAMMA ; B-CELLS ; IL-12 ; RESPONSES ; TOLERANCE
英文摘要

Based on the view that the efficacy of the immune system is associated with the maturation state of the immune cells, including dendritic cells (DC), we investigated the development and functional potential of conventional DC and plasmacytoid pre-DC (p-preDC) in spleen, thymus, and lymph nodes during mouse development. Both CD11c(+) DC and CD45RA(+) p-preDC were detected in small numbers in the thymus as early as embryonic day 17. The ratio of DC to thymocytes reached adult levels by 1 wk, although the normal CD8a(+) phenotype was not acquired until later. Significant, but low, numbers of DC and p-preDC were present in the spleen of day I newborn mice. The full complement of DC and p-preDC was not acquired until 5 wk of age. The composition of DC populations in the spleen of young mice differed significantly from that found in adult mice, with a much higher percentage (50-60% compared with 20-25%) of the CD4(-)CD8alpha(+) DC population and a much lower percentage (10-20% compared with 50-60%) of the CD4(+)D8(alpha-) DC population. Although the p-preDC of young mice showed a capacity to produce IFN-alpha comparable with that of adult mice, the conventional DC of young mice were less efficient than those of their adult counterparts in IL-12p70 and IFN-gamma production and in Ag presentation. These results suggest that the neonatal DC system is not fully developed, and innate immunity is the dominant. form of response. The complete DC system required for adaptive immunity in the mouse is not fully developed until 5 wk of age.

语种英语
WOS记录号WOS:000188005200034
Citation statistics
Cited Times:93[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65846
Collection北京大学基础医学院_免疫学系
作者单位1.Walter & Eliza Hall Inst Med Res, IG, Parkville, Vic 3050, Australia
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Dakic, A,Shao, QX,D&prime,et al. Development of the dendritic cell system during mouse ontogeny[J]. JOURNAL OF IMMUNOLOGY,2004,172(2):1018-1027.
APA Dakic, A.,Shao, QX.,D&prime.,Amico, A.,O&prime.,...&Wu, L.(2004).Development of the dendritic cell system during mouse ontogeny.JOURNAL OF IMMUNOLOGY,172(2),1018-1027.
MLA Dakic, A,et al."Development of the dendritic cell system during mouse ontogeny".JOURNAL OF IMMUNOLOGY 172.2(2004):1018-1027.
Files in This Item: Download All
File Name/Size DocType Version Access License
1018.full.pdf(646KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Dakic, A]'s Articles
[Shao, QX]'s Articles
[D&prime]'s Articles
百度学术
百度学术Similar articles in
[Dakic, A]'s Articles
[Shao, QX]'s Articles
[D&prime]'s Articles
必应学术
必应学术Similar articles in
[Dakic, A]'s Articles
[Shao, QX]'s Articles
[D&prime]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1018.full.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.