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学科主题: 药物依赖
题名:
Circadian Alteration in Neurobiology During 30 Days of Abstinence in Heroin Users
作者: Li, Su-xia1; Shi, Jie1; Epstein, David H.2; Wang, Xi1; Zhang, Xiao-li1; Bao, Yan-ping1; Zhang, Dai3; Zhang, Xiang-yang4; Kosten, Thomas R.4; Lu, Lin1
关键词: Circadian rhythms ; clock genes ; cytokines ; heroin addiction ; hormones ; peptides ; spontaneous withdrawal
刊名: BIOLOGICAL PSYCHIATRY
发表日期: 2009-05-15
DOI: 10.1016/j.biopsych.2008.11.025
卷: 65, 期:10, 页:905-912
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: BLOOD-BRAIN-BARRIER ; METHADONE-INDUCED HYPOADRENALISM ; STRESS-INDUCED RELAPSE ; NEUROPEPTIDE-Y ; CLOCK GENES ; INDUCED IMMUNOSUPPRESSION ; DIACETYLMORPHINE HEROIN ; COCAINE SENSITIZATION ; MAINTENANCE TREATMENT ; CEREBROSPINAL-FLUID
英文摘要:

Background: Previous studies have shown that individuals withdrawn from chronic opiate administration undergo substantial elevations of cortisol levels with blunted corticotropin (ACTH) rhythms and that these changes persist beyond the 7-10 days of acute withdrawal symptoms. However, there are no published studies of changes in expression of clock genes or of other neuropeptides related to circadian-rhythm regulation, which may influence relapse susceptibility.

Methods: Blood samples were collected from 8 healthy control subjects and 16 heroin addicts during pharmacologically unassisted withdrawal on the 3rd, 10th, and 30th days of abstinence at 3-hour intervals for 24 hours. Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.

Results: Compared with healthy volunteers, abstinent addicts showed disruptions in diurnal rhythms of hPER1 and hPER2 mRNA expression, along with disruptions in diurnal rhythms of cortisol, ACTH, beta-endorphin, leptin, and IL-2 release. Several of these disruptions (hPER1, hPER2, ACTH, beta-endorphin, and IL-2) persisted for the 30-day testing period, as did elevation of 24-hour levels of cortisol and decreases in 24-hour IL-2 and TNF levels.

Conclusions: These prolonged neurobiological changes may play a role in protracted opiate withdrawal symptoms and contribute to relapse vulnerability.

语种: 英语
所属项目编号: 2007013512302 ; 2009013522004 ; 2006AA02Z4D1 ; 30670773 ; 30725016
项目资助者: The National Basic Research Program of China ; The National High Technology Research and Development Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000265811300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65847
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA
3.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
4.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA

Recommended Citation:
Li, Su-xia,Shi, Jie,Epstein, David H.,et al. Circadian Alteration in Neurobiology During 30 Days of Abstinence in Heroin Users[J]. BIOLOGICAL PSYCHIATRY,2009,65(10):905-912.
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