北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma
作者: Yu, Yang; Wang, Zhao-Hui; Zhang, Liang; Yao, Hong-Juan; Zhang, Yan; Li, Ruo-Jing; Ju, Rui-Jun; Wang, Xiao-Xing; Zhou, Jia; Li, Nan; Lu, Wan-Liang1
关键词: Mitochondrial targeting topotecan-loaded ; liposomes ; Multidrug resistance ; Metastases ; Breast cancer ; Melanoma
刊名: BIOMATERIALS
发表日期: 2012-02-01
DOI: 10.1016/j.biomaterials.2011.10.085
卷: 33, 期:6, 页:1808-1820
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: VITAMIN-E-TPGS ; IN-VITRO ; PERMEABILITY TRANSITION ; MULTIDRUG-RESISTANCE ; INDUCED APOPTOSIS ; P-GLYCOPROTEIN ; CELL-DEATH ; DEQUALINIUM ; LEUKEMIA ; MECHANISMS
英文摘要:

Multidrug resistance and cancer metastases are two obstacles to a successful chemotherapy and metastases are closely associated with drug resistance. Mitochondrial targeting topotecan-loaded liposomes have been developed to overcome this resistance and resistance-related metastases. Investigations were performed on breast cancer MCF-7 and resistant MCF-7/adr cells, MCF-7 and resistant MCF-7/adr tumor spheroids, resistant MCF-7/adr cell xenografts in nude mice, and a naturally resistant B16 melanoma metastatic model in nude mice. The mitochondria] targeting topotecan-loaded liposomes were approximately 64 nm in size, and exhibited the strongest inhibitory effects on MCF-7 cells and resistant MCF-7/adr cells. Mitochondria] targeting effects were demonstrated by co-localization in mitochondria, enhanced drug content in mitochondria, dissipated mitochondrial membrane potential, opening of mitochondrial permeability transition pores, release of cytochrome C, and activation of caspase 9 and 3. The targeting liposomes had a stronger inhibitory effect on the resistant tumor spheroids in vitro, enhanced accumulation in resistant MCF-7/adr cell xenografts in mice, as well as being very effective on resistant MCF-7/adr cell xenografts in mice, and having a marked anti-metastastic effect on the naturally resistant B16 melanoma metastatic model in mice. In conclusion, mitochondrial targeting topotecan-loaded liposomes could be a promising strategy for treating resistant cancers and resistance-related metastases. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 7091005 ; 81172991
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000299986200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65850
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Yang,Wang, Zhao-Hui,Zhang, Liang,et al. Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma[J]. BIOMATERIALS,2012,33(6):1808-1820.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Yang]'s Articles
[Wang, Zhao-Hui]'s Articles
[Zhang, Liang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Yang]‘s Articles
[Wang, Zhao-Hui]‘s Articles
[Zhang, Liang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace