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学科主题: 基础医学
题名:
Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats
作者: Zhang, SH; Guo, JX; Zhang, P; Liu, YG; Jia, ZQ; Ma, KT; Li, WH; Li, LS; Zhou, CY
关键词: cardiac function ; cell transplantation ; myocardial infarction ; remodeling
刊名: LIFE SCIENCES
发表日期: 2004-04-23
DOI: 10.1016/j.lfs.2003.10.035
卷: 74, 期:23, 页:2853-2864
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: MYOCARDIAL-INFARCTION ; THERAPEUTIC ANGIOGENESIS ; COLLATERAL PERFUSION ; ISCHEMIC MYOCARDIUM ; REGIONAL FUNCTION ; CARDIAC-FUNCTION ; HEART-FAILURE ; STEM-CELLS ; IMPLANTATION ; NEOVASCULARIZATION
英文摘要:

This study was performed to evaluate the long-term effect on left ventricular function and remodeling in a rat model of bone marrow cell transplantation (BMT) into acute infarcted myocardium. After myocardial infarction was induced in inbred Lewis rats by left anterior descending artery ligation, the ischemic area was directly injected with saline, peripheral blood mononuclear cells (PB-MNCs) or bone marrow mononuclear cells (BM-MNCs). Cardiac function and structure were evaluated by echocardiography before the operation, and on day 1 and 2 months post-infarct. The collagen content, the number of vessels and the vasculogenesis were examined by histology and immunohistochemistry. We found at 2 months post-infarct, BMT significantly improved cardiac systolic function and recovered diastolic function. Transplantation of BM-MNCs, but not PB-MNCs, reversed remodeling and reduced collagen density. Vessel counts showed greater angiogenesis occur-red in the animals transplanted with BM-MNCs. Furthermore, a vascular endothelial cell-specific marker was detected in the transplanted bone marrow cells. Our data suggest that BM-MNC transplantation results in long-term improvement in left ventricular function-especially diastolic function- and remodeling, possibly related with the reduction of the amount of the collagen and enhancement of neovascularization. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000220628900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65852
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, SH,Guo, JX,Zhang, P,et al. Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats[J]. LIFE SCIENCES,2004,74(23):2853-2864.
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