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Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats
Zhang, SH; Guo, JX; Zhang, P; Liu, YG; Jia, ZQ; Ma, KT; Li, WH; Li, LS; Zhou, CY
关键词cardiac function cell transplantation myocardial infarction remodeling
刊名LIFE SCIENCES
2004-04-23
DOI10.1016/j.lfs.2003.10.035
74期:23页:2853-2864
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]MYOCARDIAL-INFARCTION ; THERAPEUTIC ANGIOGENESIS ; COLLATERAL PERFUSION ; ISCHEMIC MYOCARDIUM ; REGIONAL FUNCTION ; CARDIAC-FUNCTION ; HEART-FAILURE ; STEM-CELLS ; IMPLANTATION ; NEOVASCULARIZATION
英文摘要

This study was performed to evaluate the long-term effect on left ventricular function and remodeling in a rat model of bone marrow cell transplantation (BMT) into acute infarcted myocardium. After myocardial infarction was induced in inbred Lewis rats by left anterior descending artery ligation, the ischemic area was directly injected with saline, peripheral blood mononuclear cells (PB-MNCs) or bone marrow mononuclear cells (BM-MNCs). Cardiac function and structure were evaluated by echocardiography before the operation, and on day 1 and 2 months post-infarct. The collagen content, the number of vessels and the vasculogenesis were examined by histology and immunohistochemistry. We found at 2 months post-infarct, BMT significantly improved cardiac systolic function and recovered diastolic function. Transplantation of BM-MNCs, but not PB-MNCs, reversed remodeling and reduced collagen density. Vessel counts showed greater angiogenesis occur-red in the animals transplanted with BM-MNCs. Furthermore, a vascular endothelial cell-specific marker was detected in the transplanted bone marrow cells. Our data suggest that BM-MNC transplantation results in long-term improvement in left ventricular function-especially diastolic function- and remodeling, possibly related with the reduction of the amount of the collagen and enhancement of neovascularization. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000220628900005
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65852
专题基础医学院
作者单位1.Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100083, Peoples R China
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Zhang, SH,Guo, JX,Zhang, P,et al. Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats[J]. LIFE SCIENCES,2004,74(23):2853-2864.
APA Zhang, SH.,Guo, JX.,Zhang, P.,Liu, YG.,Jia, ZQ.,...&Zhou, CY.(2004).Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats.LIFE SCIENCES,74(23),2853-2864.
MLA Zhang, SH,et al."Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats".LIFE SCIENCES 74.23(2004):2853-2864.
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