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Selective dehydrogenation of resibufogenin and cinobufagin at 3-OH by Pseudomonas aeruginosa
Zhan, JX; Liu, WH; Guo, HZ; Zhang, YX; Guo, D
关键词resibufofenin cinobufagin selective dehydrogenation Pseudomonas aeruginosa
刊名ENZYME AND MICROBIAL TECHNOLOGY
2003-07-16
DOI10.1016/S0141-0229(03)00068-1
33期:1页:29-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]BUFADIENOLIDES ; METABOLISM
英文摘要

Microbial dehydrogenations of resibufogenin (1) and cinobufagin (2) at 3-OH by Pseudomonas aeruginosa AS 1.860 were investigated. Four products were obtained, which were identified as 3-keto-resibufogenin (3), 3-keto-cinobufagin (4), 3-keto-deacetylcinobufagin (5) and deacetylcinobufagin (6) on the basis of their spectral data. When resibufogenin was added at 22 h and transformed for 2 h, a higher transformation rate was obtained. Compounds 4, 5 and 6 were metabolites of cinobufagin by human intestinal bacteria. (C) 2003 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000183967800004
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65853
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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GB/T 7714
Zhan, JX,Liu, WH,Guo, HZ,et al. Selective dehydrogenation of resibufogenin and cinobufagin at 3-OH by Pseudomonas aeruginosa[J]. ENZYME AND MICROBIAL TECHNOLOGY,2003,33(1):29-32.
APA Zhan, JX,Liu, WH,Guo, HZ,Zhang, YX,&Guo, D.(2003).Selective dehydrogenation of resibufogenin and cinobufagin at 3-OH by Pseudomonas aeruginosa.ENZYME AND MICROBIAL TECHNOLOGY,33(1),29-32.
MLA Zhan, JX,et al."Selective dehydrogenation of resibufogenin and cinobufagin at 3-OH by Pseudomonas aeruginosa".ENZYME AND MICROBIAL TECHNOLOGY 33.1(2003):29-32.
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