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Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial
Holman, Rury R.1; Bethel, Mary A.1; Chan, Juliana C. N.2; Chiasson, Jean-Louis3; Doran, Zoe1; Ge, Junbo4; Gerstein, Hertzel5,6,7; Huo, Yong8; McMurray, John J.9; Ryden, Lars10; Liyanage, Winitha1; Schroeder, Stefan11; Tendera, Michal12; Theodorakis, Michael J.1; Tuomilehto, Jaakko13,14,15; Yang, Wenying16; Hu, Dayi17; Pan, Changyu18; ACE Study Grp
刊名AMERICAN HEART JOURNAL
2014-07-01
DOI10.1016/j.ahj.2014.03.021
168期:1页:23-29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]IMPAIRED GLUCOSE-TOLERANCE ; TYPE-2 DIABETES-MELLITUS ; OXIDATIVE STRESS ; POSTCHALLENGE HYPERGLYCEMIA ; POSTPRANDIAL HYPERGLYCEMIA ; ENDOTHELIAL DYSFUNCTION ; COAGULATION ACTIVATION ; MYOCARDIAL-INFARCTION ; PREVENTION PROGRAM ; DISEASE
英文摘要

Patients with cardiovascular disease and impaired glucose tolerance are at increased risk of cardiovascular events and type 2 diabetes mellitus (T2DM). Lifestyle modification or pharmacological intervention can delay progression to T2DM, but there is no clear evidence that they reduce cardiovascular risk in this population. Acarbose, an a-glucosidase inhibitor that lowers postprandial blood glucose, has been shown to reduce T2DM risk by 25%, and possibly cardiovascular risk in impaired glucose tolerance subjects without cardiovascular disease.

语种英语
WOS记录号WOS:000338748800005
资助机构Bayer
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65854
专题北京大学第一临床医学院_心血管内科
作者单位1.Univ Oxford, Diabet Trials Unit, Oxford, England
2.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
3.Univ Montreal, Dept Med, CRCHUM, Montreal, PQ H3C 3J7, Canada
4.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
5.McMaster Univ, Dept Med, Hamilton, ON, Canada
6.McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada
7.Hamilton Hlth Sci, Hamilton, ON, Canada
8.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
9.Univ Glasgow, Inst Cardiovasc Med Sci, BHF Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
10.Karolinska Univ Hosp Solna, Cardiol Unit, Stockholm, Sweden
11.Bayer Pharma AG, Bayer Healthcare, Berlin, Germany
12.Med Univ Silesia, Div Cardiol 3, Katowice, Poland
13.Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria
14.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
15.China Japan Friendship Hosp, Beijing, Peoples R China
16.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
17.Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
18.Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Holman, Rury R.,Bethel, Mary A.,Chan, Juliana C. N.,et al. Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial[J]. AMERICAN HEART JOURNAL,2014,168(1):23-29.
APA Holman, Rury R..,Bethel, Mary A..,Chan, Juliana C. N..,Chiasson, Jean-Louis.,Doran, Zoe.,...&ACE Study Grp.(2014).Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial.AMERICAN HEART JOURNAL,168(1),23-29.
MLA Holman, Rury R.,et al."Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial".AMERICAN HEART JOURNAL 168.1(2014):23-29.
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