北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum
作者: Dai, JG; Guo, HZ; Ye, M; Zhu, WH; Zhang, DY; Hu, Q; Han, J; Zheng, JH; Guo, DA
关键词: 4(20),11-taxadiene ; biotransformation ; cell suspension cultures ; Platycodon grandiflorum
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2003
DOI: 10.1080/1028602031000080397
卷: 5, 期:1, 页:5-10
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
英文摘要:

Platycodon grandiflorum cell suspension cultures were employed to biotransform the taxane diterpenoids 2alpha,5alpha, 10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 1 ) and 9alpha-hydroxy-2alpha, 5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 2 ). One product, 10beta-hydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene ( 3 ) was obtained from 1 and two products, 9alpha,10beta-dihydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene ( 4 ) and 10beta-hydroxy-2alpha,5alpha,9alpha,14beta-tetraacetoxy-4(20),11-taxadiene ( 5 ) were obtained from 2 incubated with Platycodon cultured cells respectively, among which 5 is characterized as a new taxoid compound. The effects of the addition stage for 1 and 2 on the biotransformation were investigated and the results revealed that: (1) the optimal addition stage for 1 was in the early logarithmic phase (6th day) of the cell growth period, in which 78% of 1 was converted and the yield for 3 reached 75%; (2) the optimal addition stage for 2 was on the mid-logarithmic phase (12th day) of the cell growth period, in which 25.3% of 2 was converted and the yields for 4 and 5 reached 18.9 and 14.5%, respectively.

语种: 英语
WOS记录号: WOS:000180484000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65858
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Dai, JG,Guo, HZ,Ye, M,et al. Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2003,5(1):5-10.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dai, JG]'s Articles
[Guo, HZ]'s Articles
[Ye, M]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dai, JG]‘s Articles
[Guo, HZ]‘s Articles
[Ye, M]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace