北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum
作者: Dai, JG; Guo, HZ; Ye, M; Zhu, WH; Zhang, DY; Hu, Q; Han, J; Zheng, JH; Guo, DA
关键词: 4(20),11-taxadiene ; biotransformation ; cell suspension cultures ; Platycodon grandiflorum
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2003
DOI: 10.1080/1028602031000080397
卷: 5, 期:1, 页:5-10
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
英文摘要:

Platycodon grandiflorum cell suspension cultures were employed to biotransform the taxane diterpenoids 2alpha,5alpha, 10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 1 ) and 9alpha-hydroxy-2alpha, 5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 2 ). One product, 10beta-hydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene ( 3 ) was obtained from 1 and two products, 9alpha,10beta-dihydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene ( 4 ) and 10beta-hydroxy-2alpha,5alpha,9alpha,14beta-tetraacetoxy-4(20),11-taxadiene ( 5 ) were obtained from 2 incubated with Platycodon cultured cells respectively, among which 5 is characterized as a new taxoid compound. The effects of the addition stage for 1 and 2 on the biotransformation were investigated and the results revealed that: (1) the optimal addition stage for 1 was in the early logarithmic phase (6th day) of the cell growth period, in which 78% of 1 was converted and the yield for 3 reached 75%; (2) the optimal addition stage for 2 was on the mid-logarithmic phase (12th day) of the cell growth period, in which 25.3% of 2 was converted and the yields for 4 and 5 reached 18.9 and 14.5%, respectively.

语种: 英语
WOS记录号: WOS:000180484000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65858
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Dai, JG,Guo, HZ,Ye, M,et al. Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2003,5(1):5-10.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dai, JG]'s Articles
[Guo, HZ]'s Articles
[Ye, M]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dai, JG]‘s Articles
[Guo, HZ]‘s Articles
[Ye, M]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace