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Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum
Dai, JG; Guo, HZ; Ye, M; Zhu, WH; Zhang, DY; Hu, Q; Han, J; Zheng, JH; Guo, DA
关键词4(20),11-taxadiene biotransformation cell suspension cultures Platycodon grandiflorum
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2003
DOI10.1080/1028602031000080397
5期:1页:5-10
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
英文摘要

Platycodon grandiflorum cell suspension cultures were employed to biotransform the taxane diterpenoids 2alpha,5alpha, 10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 1 ) and 9alpha-hydroxy-2alpha, 5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 2 ). One product, 10beta-hydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene ( 3 ) was obtained from 1 and two products, 9alpha,10beta-dihydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene ( 4 ) and 10beta-hydroxy-2alpha,5alpha,9alpha,14beta-tetraacetoxy-4(20),11-taxadiene ( 5 ) were obtained from 2 incubated with Platycodon cultured cells respectively, among which 5 is characterized as a new taxoid compound. The effects of the addition stage for 1 and 2 on the biotransformation were investigated and the results revealed that: (1) the optimal addition stage for 1 was in the early logarithmic phase (6th day) of the cell growth period, in which 78% of 1 was converted and the yield for 3 reached 75%; (2) the optimal addition stage for 2 was on the mid-logarithmic phase (12th day) of the cell growth period, in which 25.3% of 2 was converted and the yields for 4 and 5 reached 18.9 and 14.5%, respectively.

语种英语
WOS记录号WOS:000180484000002
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65858
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Dai, JG,Guo, HZ,Ye, M,et al. Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2003,5(1):5-10.
APA Dai, JG.,Guo, HZ.,Ye, M.,Zhu, WH.,Zhang, DY.,...&Guo, DA.(2003).Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,5(1),5-10.
MLA Dai, JG,et al."Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 5.1(2003):5-10.
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