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New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen
Li, Wei; Cui, Heng; Meng, Fan-Qiang; Chang, Xiao-Hong; Zhang, Guo; Liu, Bei; Li, Zi-Hai
关键词anti-idiotypic antibodies epitopes T cell tumor immunotherapy
刊名CANCER IMMUNOLOGY IMMUNOTHERAPY
2008-02-01
DOI10.1007/s00262-007-0354-8
57期:2页:143-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Immunology
研究领域[WOS]Oncology ; Immunology
关键词[WOS]CARCINOEMBRYONIC ANTIGEN ; MONOCLONAL-ANTIBODIES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; MALIGNANT-MELANOMA ; ANTITUMOR IMMUNITY ; MOLECULAR MIMICRY ; PEPTIDE MOTIFS ; CARCINOMA ; VACCINE
英文摘要

Anti-idiotype (Id) antibodies can be used to induce specific cellular immune responses against tumor antigens, but the mechanism of antigenicity is not always clear. We previously reported an anti-Id antibody, 6B11, which mimics human ovarian cancer associated antigen OC166-9. To explore the molecular basis of cellular immune response induced by 6B11, a panel of peptides derived from complementarity determining region (CDR) of 6B11 were synthesized. After a series of immunologic experiments, we found that the light chain CDR3 peptide and heavy chain CDR3 peptide were the MHC class I and class II epitopes of 6B11, respectively. The combination of MHC class I and class II epitopes is more effective than 6B11 in inducing specific cellular immune response against ovarian cancer. Our study provided the structural basis of antigenicity of 6B11. The identification of antigen-specific T cell eptitopes in 6B11 should facilitate the design of epitope-based vaccine against human ovarian cancer.

语种英语
WOS记录号WOS:000251091400001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65859
专题北京大学第二临床医学院_妇科肿瘤中心
作者单位1.Peking Univ, Gynecol Oncol Ctr, Peoples Hosp, Beijing 100871, Peoples R China
2.Beijing China Japan Friendship Hosp, Dept Gen Surg 2, Beijing, Peoples R China
3.Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA
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GB/T 7714
Li, Wei,Cui, Heng,Meng, Fan-Qiang,et al. New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2008,57(2):143-154.
APA Li, Wei.,Cui, Heng.,Meng, Fan-Qiang.,Chang, Xiao-Hong.,Zhang, Guo.,...&Li, Zi-Hai.(2008).New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen.CANCER IMMUNOLOGY IMMUNOTHERAPY,57(2),143-154.
MLA Li, Wei,et al."New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen".CANCER IMMUNOLOGY IMMUNOTHERAPY 57.2(2008):143-154.
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