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学科主题: 临床医学
题名:
New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen
作者: Li, Wei; Cui, Heng; Meng, Fan-Qiang; Chang, Xiao-Hong; Zhang, Guo; Liu, Bei; Li, Zi-Hai
关键词: anti-idiotypic antibodies ; epitopes ; T cell ; tumor immunotherapy
刊名: CANCER IMMUNOLOGY IMMUNOTHERAPY
发表日期: 2008-02-01
DOI: 10.1007/s00262-007-0354-8
卷: 57, 期:2, 页:143-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology
研究领域[WOS]: Oncology ; Immunology
关键词[WOS]: CARCINOEMBRYONIC ANTIGEN ; MONOCLONAL-ANTIBODIES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; MALIGNANT-MELANOMA ; ANTITUMOR IMMUNITY ; MOLECULAR MIMICRY ; PEPTIDE MOTIFS ; CARCINOMA ; VACCINE
英文摘要:

Anti-idiotype (Id) antibodies can be used to induce specific cellular immune responses against tumor antigens, but the mechanism of antigenicity is not always clear. We previously reported an anti-Id antibody, 6B11, which mimics human ovarian cancer associated antigen OC166-9. To explore the molecular basis of cellular immune response induced by 6B11, a panel of peptides derived from complementarity determining region (CDR) of 6B11 were synthesized. After a series of immunologic experiments, we found that the light chain CDR3 peptide and heavy chain CDR3 peptide were the MHC class I and class II epitopes of 6B11, respectively. The combination of MHC class I and class II epitopes is more effective than 6B11 in inducing specific cellular immune response against ovarian cancer. Our study provided the structural basis of antigenicity of 6B11. The identification of antigen-specific T cell eptitopes in 6B11 should facilitate the design of epitope-based vaccine against human ovarian cancer.

语种: 英语
WOS记录号: WOS:000251091400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65859
Appears in Collections:北京大学第二临床医学院_妇科肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Gynecol Oncol Ctr, Peoples Hosp, Beijing 100871, Peoples R China
2.Beijing China Japan Friendship Hosp, Dept Gen Surg 2, Beijing, Peoples R China
3.Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA

Recommended Citation:
Li, Wei,Cui, Heng,Meng, Fan-Qiang,et al. New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2008,57(2):143-154.
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