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The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats
Yan, H; Du, JB; Tang, CS
关键词hypertension hydrogen sulfide thoracic aorta
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2004-01-02
DOI10.1016/j.bbrc.2003.11.081
313期:1页:22-27
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NITRIC-OXIDE ; HEME OXYGENASE-1 ; COMPETITIVE PCR ; BLOOD-PRESSURE ; NEUROMODULATOR ; DISEASE ; GROWTH ; H2S
英文摘要

Hydrogen sulfide (H2S) is a newly found modulator in vascular system. This work showed that gene expression of cystathionine gamma-lyase (CSE), a H2S generating enzyme, and the activity of CSE in thoracic aorta were suppressed in hypertension rats. The plasma level of H2S also decreased in those rats. Exogenous administration of H2S could increase the plasma level of H′S and enhance the CSE activity of aorta. Exogenous administration of H2S also attenuated the elevation of pressure and lessened the aorta structural remodeling during the development of hypertension. In WKY rats, the gene expression and activity of CSE also decreased when the endogenous production of H2S was deprived by administration of DL-propargylglycine (specific inhibitor of CSE), accompanying the elevated pressure and the development of vascular remodeling. The results showed that endogenous HS system was involved in both the maintenance of basal blood pressure and the development of hypertension. Exogenous H2S could exert beneficial effect on the pathogenes of spontaneous hypertension. (C) 2003 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000187745900005
引用统计
被引频次:207[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65861
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, First Hosp, Dept Pediat, Beijing, Peoples R China
2.Peking Univ, First Hosp, Inst Cardiovasc Dis, Beijing, Peoples R China
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Yan, H,Du, JB,Tang, CS. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,313(1):22-27.
APA Yan, H,Du, JB,&Tang, CS.(2004).The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,313(1),22-27.
MLA Yan, H,et al."The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 313.1(2004):22-27.
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