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学科主题: 临床医学
题名:
The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats
作者: Yan, H; Du, JB; Tang, CS
关键词: hypertension ; hydrogen sulfide ; thoracic aorta
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2004-01-02
DOI: 10.1016/j.bbrc.2003.11.081
卷: 313, 期:1, 页:22-27
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NITRIC-OXIDE ; HEME OXYGENASE-1 ; COMPETITIVE PCR ; BLOOD-PRESSURE ; NEUROMODULATOR ; DISEASE ; GROWTH ; H2S
英文摘要:

Hydrogen sulfide (H2S) is a newly found modulator in vascular system. This work showed that gene expression of cystathionine gamma-lyase (CSE), a H2S generating enzyme, and the activity of CSE in thoracic aorta were suppressed in hypertension rats. The plasma level of H2S also decreased in those rats. Exogenous administration of H2S could increase the plasma level of H′S and enhance the CSE activity of aorta. Exogenous administration of H2S also attenuated the elevation of pressure and lessened the aorta structural remodeling during the development of hypertension. In WKY rats, the gene expression and activity of CSE also decreased when the endogenous production of H2S was deprived by administration of DL-propargylglycine (specific inhibitor of CSE), accompanying the elevated pressure and the development of vascular remodeling. The results showed that endogenous HS system was involved in both the maintenance of basal blood pressure and the development of hypertension. Exogenous H2S could exert beneficial effect on the pathogenes of spontaneous hypertension. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000187745900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65861
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Dept Pediat, Beijing, Peoples R China
2.Peking Univ, First Hosp, Inst Cardiovasc Dis, Beijing, Peoples R China

Recommended Citation:
Yan, H,Du, JB,Tang, CS. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,313(1):22-27.
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