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学科主题口腔医学
miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma
Jia, Lingfei1,2; Huang, Yiping3; Zheng, Yunfei1; Lyu, Mingyue1; Zhang, Chunan1; Meng, Zhen1,2; Gan, Yehua1,2; Yu, Guangyan1
关键词oral cancer tongue squamous cell carcinoma miRNA miR-375 Sp1 cyclin D1
刊名ONCOLOGY REPORTS
2015-04-01
DOI10.3892/or.2015.3759
33期:4页:2061-2071
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TRANSCRIPTION FACTOR ; CYCLIN D1 ; CANCER-CELLS ; LUNG-CANCER ; POTENTIAL BIOMARKER ; POOR-PROGNOSIS ; ORAL-CAVITY ; SP1 ; EXPRESSION ; MICRORNA-375
英文摘要

miR-375 has been implicated in various types of cancers. However, its role in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the effects of miR-375 on cell growth and the prognosis of TSCC patients. Using quantitative reverse transcription-polymerase chain reaction, we evaluated miR-375 expression in TSCC samples and TSCC cell lines. The results showed that miR-375 expression was significantly reduced in the TSCC tissues and cell lines. A low level expression of miR-375 in TSCC patients was related to poor of prognosis. Moreover, the effects of miR-375 overexpression on cell proliferation, the cell cycle and the expression of Sp1 and cyclin D1 were examined in TSCC cells. We demonstrated that overexpression of miR-375 significantly inhibited the cell proliferation and cell cycle progression in TSCC cell lines. Overexpression of miR-375 inhibited Sp1 expression by targeting the 3′ untranslated region of the Sp1 transcript. The knockdown of Sp1 expression resulted in the subsequent downregulation of cyclin D1. Taken together, our study suggests that miR-375 inhibits the cell growth, and its expression is correlated with clinical outcomes in TSCC.

语种英语
WOS记录号WOS:000350781400063
项目编号81402235 ; 81472527 ; PKUSS20140104
资助机构National Natural Science Foundation of China ; Foundation of the Peking University School and Hospital of Stomatology
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65876
专题北京大学口腔医学院
北京大学口腔医学院_外科
北京大学口腔医学院_中心实验室
作者单位1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
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GB/T 7714
Jia, Lingfei,Huang, Yiping,Zheng, Yunfei,et al. miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma[J]. ONCOLOGY REPORTS,2015,33(4):2061-2071.
APA Jia, Lingfei.,Huang, Yiping.,Zheng, Yunfei.,Lyu, Mingyue.,Zhang, Chunan.,...&Yu, Guangyan.(2015).miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma.ONCOLOGY REPORTS,33(4),2061-2071.
MLA Jia, Lingfei,et al."miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma".ONCOLOGY REPORTS 33.4(2015):2061-2071.
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