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学科主题: 口腔医学
题名:
miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma
作者: Jia, Lingfei1,2; Huang, Yiping3; Zheng, Yunfei1; Lyu, Mingyue1; Zhang, Chunan1; Meng, Zhen1,2; Gan, Yehua1,2; Yu, Guangyan1
关键词: oral cancer ; tongue squamous cell carcinoma ; miRNA ; miR-375 ; Sp1 ; cyclin D1
刊名: ONCOLOGY REPORTS
发表日期: 2015-04-01
DOI: 10.3892/or.2015.3759
卷: 33, 期:4, 页:2061-2071
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TRANSCRIPTION FACTOR ; CYCLIN D1 ; CANCER-CELLS ; LUNG-CANCER ; POTENTIAL BIOMARKER ; POOR-PROGNOSIS ; ORAL-CAVITY ; SP1 ; EXPRESSION ; MICRORNA-375
英文摘要:

miR-375 has been implicated in various types of cancers. However, its role in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the effects of miR-375 on cell growth and the prognosis of TSCC patients. Using quantitative reverse transcription-polymerase chain reaction, we evaluated miR-375 expression in TSCC samples and TSCC cell lines. The results showed that miR-375 expression was significantly reduced in the TSCC tissues and cell lines. A low level expression of miR-375 in TSCC patients was related to poor of prognosis. Moreover, the effects of miR-375 overexpression on cell proliferation, the cell cycle and the expression of Sp1 and cyclin D1 were examined in TSCC cells. We demonstrated that overexpression of miR-375 significantly inhibited the cell proliferation and cell cycle progression in TSCC cell lines. Overexpression of miR-375 inhibited Sp1 expression by targeting the 3′ untranslated region of the Sp1 transcript. The knockdown of Sp1 expression resulted in the subsequent downregulation of cyclin D1. Taken together, our study suggests that miR-375 inhibits the cell growth, and its expression is correlated with clinical outcomes in TSCC.

语种: 英语
所属项目编号: 81402235 ; 81472527 ; PKUSS20140104
项目资助者: National Natural Science Foundation of China ; Foundation of the Peking University School and Hospital of Stomatology
WOS记录号: WOS:000350781400063
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65876
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China

Recommended Citation:
Jia, Lingfei,Huang, Yiping,Zheng, Yunfei,et al. miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma[J]. ONCOLOGY REPORTS,2015,33(4):2061-2071.
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