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A preliminary study of blood-oxygen-level-dependent MRI in patients with chronic kidney disease
Pei Xin-Long1; Xie Jing-Xia1; Liu Jian-Yu1; Wang Song2; Tian Xin-Kui2
关键词Chronic kidney disease Magnetic resonance imaging BOLD Renal oxygenation
刊名MAGNETIC RESONANCE IMAGING
2012-04-01
DOI10.1016/j.mri.2011.10.003
20期:3页:330-335
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]BOLD-MRI ; INTRARENAL OXYGENATION ; MEDULLARY OXYGENATION ; WATER DIURESIS ; HYPOXIA
英文摘要

Background: Blood-oxygen-level-dependent (BOLD) magnetic resonance imaging (MRI) can provide regional measurements of oxygen content using deoxyhemoglobin paramagnetic characteristics. The apparent relaxation rate or R2*(=1/T2*) can be determined from the slope of log (intensity) versus echo time and is directly proportional to the tissue content of deoxyhemoglobin. Thus, as the level of deoxyhemoglobin increases, T2* will decrease, leading to an increase in R2*. Chronic kidney disease (CKD) can affect oxygenation levels in renal parenchyma, which influences the clinical course of the disease. The goal of this study was to detect and assess renal oxygenation levels in CKD using BOLD MRI.

Methods: Fifteen healthy subjects and 11 patients with CKD underwent a renal scan using multigradient-recalled-echo sequence with eight echoes. R2* (1/s) of the renal cortex and medulla was measured on BOLD images. Of the 11 patients, nine had biopsy-proven chronic glomerulonephritis, and two had a similar diagnosis based on clinical symptoms and investigations.

Results: Mean medullary R2* (MR2*) and cortex R2* (CR2*) levels were significantly higher in patients (22 kidneys, MR2*=24.79 +/- 4.84 s(-1), CR2*=18.97 +/- 2.72 s(-1)) than in controls (30 kidneys, MR2*=19.98 +/- 1.19 s(-1), CR2*=16.03 +/- 1.23 s(-1)) (P<.01), and MR2* was increased more than CR2*. Medullary to cortical R2* ratios (MCR2*) of patients were significantly increased when compared with those of controls (P<.01). In the patient group, estimated glomerular filtration rate levels were greater than or equal to 60 ml/min/1.73 m(2) in six patients (12 kidneys), whose MR2* and CR2* were also significantly higher than those of controls (P<.01). Serum creatinine levels were normal in seven patients (14 kidneys), whose MR2*, CR2* and MCR2* were also higher than those of controls (P<.01).

Conclusions: BOLD MRI can be used to evaluate changes in renal oxygenation in CKD, suggesting that it has the potential to be an excellent noninvasive tool for the evaluation of renal function. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000300966500004
资助机构Department of Radiology and Nephrology, Peking University Third Hospital
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65877
专题北京大学第三临床医学院_放射科
北京大学第三临床医学院_肾内科
作者单位1.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Nephrol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Pei Xin-Long,Xie Jing-Xia,Liu Jian-Yu,et al. A preliminary study of blood-oxygen-level-dependent MRI in patients with chronic kidney disease[J]. MAGNETIC RESONANCE IMAGING,2012,20(3):330-335.
APA Pei Xin-Long,Xie Jing-Xia,Liu Jian-Yu,Wang Song,&Tian Xin-Kui.(2012).A preliminary study of blood-oxygen-level-dependent MRI in patients with chronic kidney disease.MAGNETIC RESONANCE IMAGING,20(3),330-335.
MLA Pei Xin-Long,et al."A preliminary study of blood-oxygen-level-dependent MRI in patients with chronic kidney disease".MAGNETIC RESONANCE IMAGING 20.3(2012):330-335.
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