IR@PKUHSC  > 北京大学首钢医院
学科主题临床医学
Down-regulation of uterine LIF expression induced by the hormonal level disorder causes embryo implantation loss after mice exposed to carbon disulfide at pen-implantation
Wang, Shuting1; Sun, Yuan1,2; Wu, Yanling1; Zhang, Tongchao1; Hu, Chengxia1,3; Zhang, Bingzhen1,4; Wang, Zhiping1
关键词Carbon disulfide Embryo implantation Leukemia inhibitory factor DNA damage Progesterone Oestrogen
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-11-06
DOI10.1016/j.bbrc.2015.09.141
467期:1页:7-13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]LEUKEMIA-INHIBITORY FACTOR ; DNA-DAMAGE ; IN-UTERO ; ENDOMETRIAL RECEPTIVITY ; INFERTILITY ; FERTILITY ; INCREASES ; BENZENE ; CELLS ; ONSET
英文摘要

Carbon disulfide (CS2) exposure can cause embryo implantation loss but the mechanism remains unclear. Earlier study revealed that the 4th day of gestation (GD4) and GD5 were the most sensitive exposure time on which the number of implanted embryos decreased obviously in mice. Leukemia inhibitory factor (LIF) in maternal uterine tissue is involved in embryo implantation, which is produced by endometrium and Th2 cells that participate in cellular adhesion of maternal-fetal interface. We herein investigated the effect of CS2 on the expression of LIF in uterine tissue and its regulatory mechanism in Kunming mice. Exposure was on GD3, GD4, GD5 and GD6, respectively, single administration (631.4 mg/kg), and the indexes were arranged in time series after exposure. The results showed that LIF gene breakage was captured at the 18th hour after exposure by Comet-FISH and the protein and mRNA of LIF in uterine tissue were down-regulated after exposure through the pen-implantation period. In addition, sex steroid hormones, progesterone (P-4) and oestrogen (E-2) were detected since they can stimulate synthesis of LIF from endometrial cells. Results showed that P-4 and E-2 in serum were down-regulated at all the endpoints of CS2 exposure groups. These findings suggested that the down-regulated LIF induced by the decreased P-4 and E-2 after mice exposure to CS2 might be important reasons for implantation disorders. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81072275 ; 81472950
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000363712900002
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65882
Collection北京大学首钢医院
作者单位1.Peking Univ, Shougang Hosp, Beijing 100041, Peoples R China
2.Shandong Univ, Sch Publ Hlth, Jinan 250012, Shandong, Peoples R China
3.Yantai Ctr Dis Control & Prevent, Yantai 264000, Shandong, Peoples R China
4.Shandong Prov Hlth Supervis Inst, Jinan 250031, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shuting,Sun, Yuan,Wu, Yanling,et al. Down-regulation of uterine LIF expression induced by the hormonal level disorder causes embryo implantation loss after mice exposed to carbon disulfide at pen-implantation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,467(1):7-13.
APA Wang, Shuting.,Sun, Yuan.,Wu, Yanling.,Zhang, Tongchao.,Hu, Chengxia.,...&Wang, Zhiping.(2015).Down-regulation of uterine LIF expression induced by the hormonal level disorder causes embryo implantation loss after mice exposed to carbon disulfide at pen-implantation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,467(1),7-13.
MLA Wang, Shuting,et al."Down-regulation of uterine LIF expression induced by the hormonal level disorder causes embryo implantation loss after mice exposed to carbon disulfide at pen-implantation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 467.1(2015):7-13.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Wang, Shuting]'s Articles
[Sun, Yuan]'s Articles
[Wu, Yanling]'s Articles
百度学术
百度学术Similar articles in
[Wang, Shuting]'s Articles
[Sun, Yuan]'s Articles
[Wu, Yanling]'s Articles
必应学术
必应学术Similar articles in
[Wang, Shuting]'s Articles
[Sun, Yuan]'s Articles
[Wu, Yanling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.