IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity
Yu, F; Zhao, MH; Zhang, YK; Zhang, Y; Wang, HY
关键词anti-endothelial cell antibodies (AECA) antineutrophil cytoplasmic antibodies (ANCA) propylthiouracil (PTU) vasculitis
刊名CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2005-03-01
DOI10.1111/j.1365-2249.2005.02725.x
139期:3页:569-574
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ANTINEUTROPHIL CYTOPLASM ANTIBODIES ; ADHESION MOLECULE EXPRESSION ; ENDOTHELIAL-CELLS ; WEGENERS-GRANULOMATOSIS ; SYSTEMIC VASCULITIS ; ANTIMYELOPEROXIDASE ANTIBODIES ; ANTI-PR3 ANTIBODIES ; KAWASAKI-DISEASE ; TNF-ALPHA ; MPO-ANCA
英文摘要

Increasing evidence has demonstrated that propylthiouracil (PTU) could induce ANCA positive vasculitis. However, our previous work has suggested that only one-fifth of the PTU-induced ANCA positive patients had clinical vasculitis and so the mechanism is not clear. Anti-endothelial cell antibodies (AECA) have been implicated in the pathogenesis of various vasculitides, including primary ANCA positive systemic vasculitis. The purpose of this study is to investigate the prevalence of AECA and their possible role in the pathogenesis of patients with PTU-induced ANCA positive vasculitis. Sera from 11 patients with PTU-induced ANCA positive vasculitis at both active and quiescent phases, and sera from 10 patients with PTU-induced ANCA but without clinical vasculitis, were studied. Sera from 30 healthy blood donors were collected as normal controls. Soluble proteins from 1% Triton-100 extracted in vitro cultured human umbilical vein endothelial cells were used as antigens and an immunoblotting technique was performed to determine the presence of AECA, and their specific target antigens were identified. In patients with PTU-induced ANCA positive vasculitis, 10 of the 11 patients in an active phase of disease were serum IgG-AECA positive and six protein bands of endothelial antigens could be blotted (61 kD, 69 kD, 77 kD, 85 kD, 91 kD and 97 kD). However, in the quiescent phase, seven of the 10 positive sera turned negative. None of the ANCA positive but vasculitis negative patients or normal controls were AECA positive. In conclusion, AECA could be found in sera from patients with PTU-induced ANCA positive vasculitis and were associated more closely with vasculitic disease activity.

语种英语
WOS记录号WOS:000227226900023
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65886
Collection北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Inst Renal Div, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Yu, F,Zhao, MH,Zhang, YK,et al. Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2005,139(3):569-574.
APA Yu, F,Zhao, MH,Zhang, YK,Zhang, Y,&Wang, HY.(2005).Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,139(3),569-574.
MLA Yu, F,et al."Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 139.3(2005):569-574.
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