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Pharmacological neuroprotection after perinatal asphyxia
Fan, Xiyong1,2,3; van Bel, Frank1
关键词Brain asphyxia neonate neuroprotection pharmacology
刊名JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
2010-10-01
DOI10.3109/14767058.2010.505052
suppl.3页:17-19
收录类别SCI ; ISTP
文章类型Review
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]HYPOXIA-ISCHEMIA ; BRAIN-INJURY ; NEONATAL HYPOXIA/ISCHEMIA ; WHITE-MATTER ; ERYTHROPOIETIN ; RATS ; INDOMETHACIN ; NEUROGENESIS ; INFLAMMATION ; ALLOPURINOL
英文摘要

Recent progress has provided us with several promising neuroprotective compounds to reduce perinatal hypoxic-ischemic (HI) brain injury. In the early post HI phase, therapies can be concentrated on ion channel blockage (Xenon), anti-oxidation (allopurinol, 2-iminobiotin, and indomethacin), anti-inflammation (erythropoietin [EPO], melatonin), and anti-apoptosis (nuclear factor kappa B [NF-kappa B]and c-jun N-terminal kinase [JNK] inhibitors); in the later phase, therapies should be targeted to promote neuronal regeneration by stimulation of neurotrophic properties of the neonatal brain (EPO, growth factors, stem cells transplantation). Combination of pharmacological interventions with moderate hypothermia, which is the only established therapy for post HI brain injury, is probably the next step to fight HI brain damage in the clinical setting. Further studies should be concentrated on more rational pharmacological strategies by determining the optimal time and dose to inhibit the various potentially destructive molecular pathways and/or to enhance endogenous repair meanwhile avoiding the adverse effects.

语种英语
WOS记录号WOS:000282588900005
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65887
专题北京大学第一临床医学院_儿科
作者单位1.Univ Med Ctr, Dept Neonatol, NL-3508 AB Utrecht, Netherlands
2.Univ Med Ctr, Lab Neuroimmunol & Dev Origins Dis, NL-3508 AB Utrecht, Netherlands
3.Peking Univ, Hosp 1, Dept Paediat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Fan, Xiyong,van Bel, Frank. Pharmacological neuroprotection after perinatal asphyxia[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,2010,suppl.3:17-19.
APA Fan, Xiyong,&van Bel, Frank.(2010).Pharmacological neuroprotection after perinatal asphyxia.JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,suppl.3,17-19.
MLA Fan, Xiyong,et al."Pharmacological neuroprotection after perinatal asphyxia".JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE suppl.3(2010):17-19.
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