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学科主题: 临床医学
题名:
Pharmacological neuroprotection after perinatal asphyxia
作者: Fan, Xiyong1,2,3; van Bel, Frank1
关键词: Brain ; asphyxia ; neonate ; neuroprotection ; pharmacology
刊名: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
发表日期: 2010-10-01
DOI: 10.3109/14767058.2010.505052
卷: suppl.3, 页:17-19
收录类别: SCI ; ISTP
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: HYPOXIA-ISCHEMIA ; BRAIN-INJURY ; NEONATAL HYPOXIA/ISCHEMIA ; WHITE-MATTER ; ERYTHROPOIETIN ; RATS ; INDOMETHACIN ; NEUROGENESIS ; INFLAMMATION ; ALLOPURINOL
英文摘要:

Recent progress has provided us with several promising neuroprotective compounds to reduce perinatal hypoxic-ischemic (HI) brain injury. In the early post HI phase, therapies can be concentrated on ion channel blockage (Xenon), anti-oxidation (allopurinol, 2-iminobiotin, and indomethacin), anti-inflammation (erythropoietin [EPO], melatonin), and anti-apoptosis (nuclear factor kappa B [NF-kappa B]and c-jun N-terminal kinase [JNK] inhibitors); in the later phase, therapies should be targeted to promote neuronal regeneration by stimulation of neurotrophic properties of the neonatal brain (EPO, growth factors, stem cells transplantation). Combination of pharmacological interventions with moderate hypothermia, which is the only established therapy for post HI brain injury, is probably the next step to fight HI brain damage in the clinical setting. Further studies should be concentrated on more rational pharmacological strategies by determining the optimal time and dose to inhibit the various potentially destructive molecular pathways and/or to enhance endogenous repair meanwhile avoiding the adverse effects.

语种: 英语
WOS记录号: WOS:000282588900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65887
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Univ Med Ctr, Dept Neonatol, NL-3508 AB Utrecht, Netherlands
2.Univ Med Ctr, Lab Neuroimmunol & Dev Origins Dis, NL-3508 AB Utrecht, Netherlands
3.Peking Univ, Hosp 1, Dept Paediat, Beijing 100871, Peoples R China

Recommended Citation:
Fan, Xiyong,van Bel, Frank. Pharmacological neuroprotection after perinatal asphyxia[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,2010,suppl.3:17-19.
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