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Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
Tan, YL; Zhou, DF; Zhang, XY
关键词tardive dyskinesia brain-derived neurotrophic factor neurotrophin schizophrenia symptom sex difference
刊名SCHIZOPHRENIA RESEARCH
2005-05-01
DOI10.1016/j.schres.2004.08.004
74期:2-3页:263-270
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]BDNF MESSENGER-RNA ; RAT HIPPOCAMPUS ; OXIDATIVE STRESS ; NEURONS ; EXPRESSION ; SERUM ; TRANSPORT ; GLUTAMATE ; DAMAGE
英文摘要

Neurodegenerative processes may be involved in the pathogenesis of tardive dyskinesia (TD). Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) plays a critical role in the maintenance of functional neurons. The present study was to examine plasma BDNF levels and the relationship among BDNF level, psychopathological and tardive dyskinesia symptoms in schizophrenic patients with TD. Eighty schizophrenic patients with TD were compared with 45 schizophrenic patients without TD, as well as with 45 age-, sex-matched normal controls. The severity of TD was assessed using the Abnormal Involuntary Movement Scale (AIMS). The psychopathology of patients was assessed by the Positive and Negative Syndrome Scale (PANSS). Plasma BDNF levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). The results showed that the patients with TD had lower plasma BDNF levels than those without TD, and than that of normal controls. In the patients with TD, plasma BDNF levels was inversely correlated with AIMS total score, and with PANSS negative subscore. Female patients had significantly lower plasma BDNF levels than male TD patients. Our results suggest that decreased BDNF may play an important role in the pathophysiology of TD. There may be a relationship between decreased BDNF levels and dyskinetic movements associated with TD. (C) 2004 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000227481800013
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被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65890
专题北京大学精神卫生研究所
作者单位1.Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Dept Psychiat,Ribicoff Labs, New Haven, CT 06508 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
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Tan, YL,Zhou, DF,Zhang, XY. Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements[J]. SCHIZOPHRENIA RESEARCH,2005,74(2-3):263-270.
APA Tan, YL,Zhou, DF,&Zhang, XY.(2005).Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements.SCHIZOPHRENIA RESEARCH,74(2-3),263-270.
MLA Tan, YL,et al."Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements".SCHIZOPHRENIA RESEARCH 74.2-3(2005):263-270.
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