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学科主题: 临床医学
题名:
Association analysis of BANK1 gene with psoriasis in Southern Han Chinese
作者: Zhang, X.1; Fei, Z.2; Wan, J.3; Xu, J.4; Yu, B.5; Guan, M.1,4
刊名: INTERNATIONAL JOURNAL OF IMMUNOGENETICS
发表日期: 2011-12-01
DOI: 10.1111/j.1744-313X.2011.01045.x
卷: 38, 期:6, 页:507-512
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Immunology
研究领域[WOS]: Genetics & Heredity ; Immunology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; DNA MELTING ANALYSIS ; FUNCTIONAL VARIANTS ; AUTOANTIBODIES ; POPULATION ; SUSCEPTIBILITY ; KERATINOCYTES ; REPLICATION ; METABOLISM ; SCLEROSIS
英文摘要:

Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This study aimed to determine the association between three functional SNPs of BANK1 (rs10516487, rs17266594 and rs3733197) with psoriasis in Southern Han Chinese population by determining their frequency in 242 patients with psoriasis and 317 healthy individuals. The genotype frequencies of the detected polymorphisms were analysed in relation to the susceptibility of psoriasis. Our data show that there is no significant difference in genotype distribution for the three BANK1 SNPs between patients and healthy controls. The AA frequency of rs3733197 is significantly higher in patients with psoriasis onset before the age of 23 than in those with late disease onset (P = 0.0069). In addition, analysis on BANK1 haplotype also suggests a protective role for TGC and CAT haplotype from psoriasis (OR 0.55, 95% CI: 0.340.89; P = 0.0144; OR 0.62, 95% CI: 0.420.92; P = 0.0175), whereas CGT haplotype is associated with increased risk of the disease (OR 1.38, 95% CI: 1.051.81, P = 0.0203). Overall, our result indicates that polymorphism in BANK1 is associated with susceptibility to psoriasis in Southern Han Chinese.

语种: 英语
WOS记录号: WOS:000297257800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65891
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Lab Med,Cent Lab, Shanghai 200433, Peoples R China
2.Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Tradit Chinese Med, Shanghai 200433, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen, Peoples R China
4.Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Peoples R China

Recommended Citation:
Zhang, X.,Fei, Z.,Wan, J.,et al. Association analysis of BANK1 gene with psoriasis in Southern Han Chinese[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2011,38(6):507-512.
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