IR@PKUHSC  > 北京大学临床肿瘤学院  > 临床实验室
学科主题临床医学
Association of LAPTM4B gene polymorphism with breast cancer susceptibility
Fan, Meirong1; Liu, Ye1; Zhou, Rouli2; Zhang, Qingyun1
关键词Breast cancer LAPTM4B Polymorphism Susceptibility
刊名CANCER EPIDEMIOLOGY
2012-08-01
DOI10.1016/j.canep.2011.12.004
36期:4页:364-368
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]Oncology ; Public, Environmental & Occupational Health
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; CARCINOMA ; PROGRESSION ; EXPRESSION ; OVEREXPRESSION ; CHEMOTHERAPY ; RESISTANCE ; TUMORS
英文摘要

Background: Lysosome associated protein transmembrane 4 beta (LAPTM4B) was a cancer-associated gene that is mapped to chromosome 8q22 with seven exons and six introns. LAPTM4B gene polymorphism has been reported to be significantly associated with susceptibility of several solid tumors.

Methods: We performed a case-control study was to investigate the association between LAPTM4B polymorphism and the risk of breast cancer in 732 breast cancer patients and 649 controls.

Results: A significant difference in the frequency of LAPTM4B*2 was observed between the patients and the controls (P < 0.01). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was significantly associated with breast cancer occurrence, with adjusted odds ratios of 1.387 (95% CI = 1.111-1.730) for LAPTM4B*1/2 and 1.592 (95% CI = 1.043-2.430) for LAPTM4B*2/2 genotype.

Conclusion: Our results suggested that LAPTM4B* 2 is associated with an increased risk of breast cancer in the Chinese women population and may be a risk factor of breast cancer. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000307216700016
项目编号81071422
资助机构National Natural Science Foundation of China
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65899
专题北京大学临床肿瘤学院_临床实验室
北京大学临床肿瘤学院_检验科
作者单位1.Peking Univ, Dept Clin Lab, Beijing Canc Hosp & Inst, Minist Educ,Sch Oncol,Key Lab Carcinogenesis & Tr, Beijing 100142, Peoples R China
2.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Fan, Meirong,Liu, Ye,Zhou, Rouli,et al. Association of LAPTM4B gene polymorphism with breast cancer susceptibility[J]. CANCER EPIDEMIOLOGY,2012,36(4):364-368.
APA Fan, Meirong,Liu, Ye,Zhou, Rouli,&Zhang, Qingyun.(2012).Association of LAPTM4B gene polymorphism with breast cancer susceptibility.CANCER EPIDEMIOLOGY,36(4),364-368.
MLA Fan, Meirong,et al."Association of LAPTM4B gene polymorphism with breast cancer susceptibility".CANCER EPIDEMIOLOGY 36.4(2012):364-368.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fan, Meirong]的文章
[Liu, Ye]的文章
[Zhou, Rouli]的文章
百度学术
百度学术中相似的文章
[Fan, Meirong]的文章
[Liu, Ye]的文章
[Zhou, Rouli]的文章
必应学术
必应学术中相似的文章
[Fan, Meirong]的文章
[Liu, Ye]的文章
[Zhou, Rouli]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。