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学科主题: 临床医学
题名:
Association of LAPTM4B gene polymorphism with breast cancer susceptibility
作者: Fan, Meirong1; Liu, Ye1; Zhou, Rouli2; Zhang, Qingyun1
关键词: Breast cancer ; LAPTM4B ; Polymorphism ; Susceptibility
刊名: CANCER EPIDEMIOLOGY
发表日期: 2012-08-01
DOI: 10.1016/j.canep.2011.12.004
卷: 36, 期:4, 页:364-368
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: INDEPENDENT PROGNOSTIC MARKER ; CARCINOMA ; PROGRESSION ; EXPRESSION ; OVEREXPRESSION ; CHEMOTHERAPY ; RESISTANCE ; TUMORS
英文摘要:

Background: Lysosome associated protein transmembrane 4 beta (LAPTM4B) was a cancer-associated gene that is mapped to chromosome 8q22 with seven exons and six introns. LAPTM4B gene polymorphism has been reported to be significantly associated with susceptibility of several solid tumors.

Methods: We performed a case-control study was to investigate the association between LAPTM4B polymorphism and the risk of breast cancer in 732 breast cancer patients and 649 controls.

Results: A significant difference in the frequency of LAPTM4B*2 was observed between the patients and the controls (P < 0.01). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was significantly associated with breast cancer occurrence, with adjusted odds ratios of 1.387 (95% CI = 1.111-1.730) for LAPTM4B*1/2 and 1.592 (95% CI = 1.043-2.430) for LAPTM4B*2/2 genotype.

Conclusion: Our results suggested that LAPTM4B* 2 is associated with an increased risk of breast cancer in the Chinese women population and may be a risk factor of breast cancer. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81071422
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000307216700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65899
Appears in Collections:北京大学临床肿瘤学院_临床实验室_期刊论文

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作者单位: 1.Peking Univ, Dept Clin Lab, Beijing Canc Hosp & Inst, Minist Educ,Sch Oncol,Key Lab Carcinogenesis & Tr, Beijing 100142, Peoples R China
2.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100142, Peoples R China

Recommended Citation:
Fan, Meirong,Liu, Ye,Zhou, Rouli,et al. Association of LAPTM4B gene polymorphism with breast cancer susceptibility[J]. CANCER EPIDEMIOLOGY,2012,36(4):364-368.
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