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学科主题临床医学
Association of LAPTM4B gene polymorphism with breast cancer susceptibility
Fan, Meirong1; Liu, Ye1; Zhou, Rouli2; Zhang, Qingyun1
关键词Breast cancer LAPTM4B Polymorphism Susceptibility
刊名CANCER EPIDEMIOLOGY
2012-08-01
DOI10.1016/j.canep.2011.12.004
36期:4页:364-368
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Public, Environmental & Occupational Health
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology ; Public, Environmental & Occupational Health
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; CARCINOMA ; PROGRESSION ; EXPRESSION ; OVEREXPRESSION ; CHEMOTHERAPY ; RESISTANCE ; TUMORS
英文摘要

Background: Lysosome associated protein transmembrane 4 beta (LAPTM4B) was a cancer-associated gene that is mapped to chromosome 8q22 with seven exons and six introns. LAPTM4B gene polymorphism has been reported to be significantly associated with susceptibility of several solid tumors.

Methods: We performed a case-control study was to investigate the association between LAPTM4B polymorphism and the risk of breast cancer in 732 breast cancer patients and 649 controls.

Results: A significant difference in the frequency of LAPTM4B*2 was observed between the patients and the controls (P < 0.01). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was significantly associated with breast cancer occurrence, with adjusted odds ratios of 1.387 (95% CI = 1.111-1.730) for LAPTM4B*1/2 and 1.592 (95% CI = 1.043-2.430) for LAPTM4B*2/2 genotype.

Conclusion: Our results suggested that LAPTM4B* 2 is associated with an increased risk of breast cancer in the Chinese women population and may be a risk factor of breast cancer. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81071422
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000307216700016
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65899
Collection北京大学临床肿瘤学院_临床实验室
作者单位1.Peking Univ, Dept Clin Lab, Beijing Canc Hosp & Inst, Minist Educ,Sch Oncol,Key Lab Carcinogenesis & Tr, Beijing 100142, Peoples R China
2.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Fan, Meirong,Liu, Ye,Zhou, Rouli,et al. Association of LAPTM4B gene polymorphism with breast cancer susceptibility[J]. CANCER EPIDEMIOLOGY,2012,36(4):364-368.
APA Fan, Meirong,Liu, Ye,Zhou, Rouli,&Zhang, Qingyun.(2012).Association of LAPTM4B gene polymorphism with breast cancer susceptibility.CANCER EPIDEMIOLOGY,36(4),364-368.
MLA Fan, Meirong,et al."Association of LAPTM4B gene polymorphism with breast cancer susceptibility".CANCER EPIDEMIOLOGY 36.4(2012):364-368.
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