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学科主题临床医学
Mesenchymal Stem Cells versus Mesenchymal Stem Cells Combined with Cord Blood for Engraftment Failure after Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Label, Randomized Trial
Xiong, Yi-Ying1; Fan, Qian1; Huang, Fen1; Zhang, Yu1; Wang, Yu2; Chen, Xiao-Yong3; Fan, Zhi-Ping1; Zhou, Hong-Sheng1; Xiao, Yang4; Xu, Xiao-Jun5; Dai, Min1; Xu, Na1; Sun, Jing1; Xiang, Peng3; Huang, Xiao-Jun2; Liu, Qi-Fa1
关键词Engraftment failure Mesenchymal stem cells Cord blood Autologous hematopoietic stem cell transplantation
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2014-02-01
DOI10.1016/j.bbmt.2013.11.002
20期:2页:236-242
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]SEVERE APLASTIC-ANEMIA ; STROMAL CELLS ; BONE-MARROW ; RESPONSE CRITERIA ; PLATELET RECOVERY ; PROGENITOR CELLS ; THERAPY ; LYMPHOMA ; RECONSTITUTION ; COTRANSPLANTATION
英文摘要

Engraftment failure (EF) after autologous hematopoietic stem cell transplantation is a serious complication. We prospectively evaluated the effects and safeties of mesenchymal stem cells (MSCs) alone and MSCs combined with cord blood (CB) for EF. Twenty-two patients were randomized to receive MSCs (MSC group; n = 11) or MSCs plus CB (CB group; n = 11). Patients with no response (NR) to MSCs received the therapeutic schedule in the CB group, and those patients with partial response (PR) in the MSC group and patients without complete remission (CR) in the CB group received another cycle of MSC treatment. Patients who did not achieve CR after 2 cycles of treatments received other treatments, including allogeneic HSCT. After the first treatment cycle, response was seen in 7 of 11 patients in the MSC group and in 9 of 11 in the CB group (P = .635), with a significant difference in neutrophil reconstruction between the 2 groups (P = .030). After 2 treatment cycles, 16 patients achieved CR, 3 achieved PR, and 3 had NR. No patient experienced graft-versus-host disease (GVHD). With a median follow-up of 345 d (range, 129 to 784 d) post-transplantation, 18 patients remained alive and 4 had died (3 from primary disease relapse and 1 from cytomegalovirus pneumonia). The 2-year overall survival, disease-free survival, and cumulative incidence of tumor relapse post-transplantation were 75.2% +/- 12.0%, 79.5% +/- 9.4%, and 20.5% +/- 9.4%, respectively. Our data indicate that the 2 strategies are effective for EF and do not result in GVHD or increase the risk of tumor relapse, but the MSC plus CB regimen has a superior effect on neutrophil reconstruction. (C) 2014 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000331155300015
项目编号2011AA020105 ; 81270647 ; 81000231 ; 201154300104 ; 2009A03020007 ; 201202017
资助机构National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou City, China ; Science and Technology Planning Project of Guangdong Province, China ; National Public Health Grand Research Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65903
专题北京大学第二临床医学院_血液科
作者单位1.Southern Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou 510515, Guangdong, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
3.Sun Yat Sen Univ, Ctr Stem Cell Biol & Tissue Engn, Guangzhou 510275, Guangdong, Peoples R China
4.PIA, Gen Hosp Guangzhou Mil Command, Dept Hematol, Guangzhou, Guangdong, Peoples R China
5.Sun Yat Sen Univ, Zhongshan Peoples Hosp, Dept Hematol, Zhongshan, Peoples R China
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Xiong, Yi-Ying,Fan, Qian,Huang, Fen,et al. Mesenchymal Stem Cells versus Mesenchymal Stem Cells Combined with Cord Blood for Engraftment Failure after Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Label, Randomized Trial[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2014,20(2):236-242.
APA Xiong, Yi-Ying.,Fan, Qian.,Huang, Fen.,Zhang, Yu.,Wang, Yu.,...&Liu, Qi-Fa.(2014).Mesenchymal Stem Cells versus Mesenchymal Stem Cells Combined with Cord Blood for Engraftment Failure after Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Label, Randomized Trial.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,20(2),236-242.
MLA Xiong, Yi-Ying,et al."Mesenchymal Stem Cells versus Mesenchymal Stem Cells Combined with Cord Blood for Engraftment Failure after Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Label, Randomized Trial".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 20.2(2014):236-242.
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