北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk
作者: Zhan, Yiqiang1; Dong, Ying2; Tang, Zheng1; Zhang, Fen3; Hu, Dayi4; Yu, Jinming1,5
关键词: uric acid ; ankle brachial index ; peripheral arterial disease ; gender differences
刊名: ANGIOLOGY
发表日期: 2015-08-01
DOI: 10.1177/0003319714566228
卷: 66, 期:7, 页:687-691
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PERIPHERAL ARTERIAL-DISEASE ; CHRONIC KIDNEY-DISEASE ; ALL-CAUSE MORTALITY ; SMOOTH-MUSCLE-CELL ; CHINESE PATIENTS ; INSULIN-RESISTANCE ; PREDICTIVE-VALUE ; HYPERTENSION ; ASSOCIATION ; POPULATION
英文摘要:

Uric acid (UA) has been reported to be associated with cardiovascular disease (CVD) in caucasians. However, it is unclear whether this association remains significant in a Chinese population. The present study aimed to investigate the association between UA and low ankle brachial index (ABI), a measurement of peripheral arterial disease, in Chinese patients. A total of 6262 hospital-based patients with high CVD risk were enrolled. Low ABI was defined as ABI 0.9 in either side. Low ABI was detected in 1390 (22.2%) patients. Higher UA was significantly associated with higher risk of low ABI and modified by gender (P = .0045). After adjusting for age, body mass index, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, fasting glucose, hypertension, and smoking, participants in the highest quartile of UA exhibited 37% (odds ratio [OR]:1.37, 95% confidence interval [CI]: 1.03-1.82) higher risk of low ABI compared to those in the lowest quartile in men, while OR (95% CI) was 1.69 (1.29-2.22) for women. However, when kidney function was further adjusted, the associations were attenuated in both men and women and were significant only in women. The results were suggestive of higher UA associating with higher risk of low ABI in women, and the association was largely driven by kidney function, especially in men.

语种: 英语
WOS记录号: WOS:000358577600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65904
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Fudan Univ, Sch Publ Hlth, Inst Clin Epidemiol, Shanghai 200032, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Basic Med, Dept Prevent Med, Shanghai, Peoples R China
3.Minhang Ctr Dis Control & Prevent, Dept Chron Dis Prevent, Shanghai, Peoples R China
4.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China
5.Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China

Recommended Citation:
Zhan, Yiqiang,Dong, Ying,Tang, Zheng,et al. Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk[J]. ANGIOLOGY,2015,66(7):687-691.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhan, Yiqiang]'s Articles
[Dong, Ying]'s Articles
[Tang, Zheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhan, Yiqiang]‘s Articles
[Dong, Ying]‘s Articles
[Tang, Zheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace