IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk
Zhan, Yiqiang1; Dong, Ying2; Tang, Zheng1; Zhang, Fen3; Hu, Dayi4; Yu, Jinming1,5
关键词uric acid ankle brachial index peripheral arterial disease gender differences
刊名ANGIOLOGY
2015-08-01
DOI10.1177/0003319714566228
66期:7页:687-691
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]PERIPHERAL ARTERIAL-DISEASE ; CHRONIC KIDNEY-DISEASE ; ALL-CAUSE MORTALITY ; SMOOTH-MUSCLE-CELL ; CHINESE PATIENTS ; INSULIN-RESISTANCE ; PREDICTIVE-VALUE ; HYPERTENSION ; ASSOCIATION ; POPULATION
英文摘要

Uric acid (UA) has been reported to be associated with cardiovascular disease (CVD) in caucasians. However, it is unclear whether this association remains significant in a Chinese population. The present study aimed to investigate the association between UA and low ankle brachial index (ABI), a measurement of peripheral arterial disease, in Chinese patients. A total of 6262 hospital-based patients with high CVD risk were enrolled. Low ABI was defined as ABI 0.9 in either side. Low ABI was detected in 1390 (22.2%) patients. Higher UA was significantly associated with higher risk of low ABI and modified by gender (P = .0045). After adjusting for age, body mass index, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, fasting glucose, hypertension, and smoking, participants in the highest quartile of UA exhibited 37% (odds ratio [OR]:1.37, 95% confidence interval [CI]: 1.03-1.82) higher risk of low ABI compared to those in the lowest quartile in men, while OR (95% CI) was 1.69 (1.29-2.22) for women. However, when kidney function was further adjusted, the associations were attenuated in both men and women and were significant only in women. The results were suggestive of higher UA associating with higher risk of low ABI in women, and the association was largely driven by kidney function, especially in men.

语种英语
WOS记录号WOS:000358577600015
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65904
专题北京大学第二临床医学院
作者单位1.Fudan Univ, Sch Publ Hlth, Inst Clin Epidemiol, Shanghai 200032, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Basic Med, Dept Prevent Med, Shanghai, Peoples R China
3.Minhang Ctr Dis Control & Prevent, Dept Chron Dis Prevent, Shanghai, Peoples R China
4.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China
5.Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714
Zhan, Yiqiang,Dong, Ying,Tang, Zheng,et al. Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk[J]. ANGIOLOGY,2015,66(7):687-691.
APA Zhan, Yiqiang,Dong, Ying,Tang, Zheng,Zhang, Fen,Hu, Dayi,&Yu, Jinming.(2015).Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk.ANGIOLOGY,66(7),687-691.
MLA Zhan, Yiqiang,et al."Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk".ANGIOLOGY 66.7(2015):687-691.
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