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Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions
Chou, Yuan I. Scarlet1; Kong, Jinge2,3; Song, Rui1; Yan, Lulu1; Zheng, Lemin4,5,6; Zhang, Yongzhen1
关键词Coronary heart disease coronary intermediate lesion fractional flow reserve intravenous ultrasound platelet-derived microparticles
刊名BIOMARKERS
2014-12-01
DOI10.3109/1354750X.2014.981293
19期:8页:684-692
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]ELEVATION MYOCARDIAL-INFARCTION ; FRACTIONAL FLOW RESERVE ; ASSOCIATION TASK-FORCE ; ARTERY-DISEASE ; NITRIC-OXIDE ; PRACTICE GUIDELINES ; INTERVENTION ; ANGIOGRAPHY ; ATHEROSCLEROSIS ; PERSPECTIVES
英文摘要

This study was to investigate the utility of platelet-derived microparticles (PMPs) to detect coronary intermediate lesions. Fifty-two patients with coronary intermediate lesions and 24 subjects with normal coronary arteries were enrolled. In the former group, 31 patients accepted both intravenous ultrasound (IVUS) and fractional flow reserve (FFR). Results showed that the level of PMPs was significantly higher in the intermediate lesion group and PMPs titer was positively correlated with thromboxane B2, platelet activating factor, endothelin-1, and neutrophil to lymphocyte ratio. The level of PMPs also increased after IVUS/FFR, suggesting platelet activation and endothelial dysfunction.

语种英语
WOS记录号WOS:000345498100010
项目编号2011CB503900 ; 7122200 ; 81170101 ; 81370235 ; 7122106
资助机构Leading Academic Discipline Project of Beijing Education Bureau ; Beijing Natural Sciences Foundation ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65905
专题北京大学基础医学院
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Dept Neurobiol,Sch Basic Med Sci,Key Lab Neurosci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Syst Biomed, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
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GB/T 7714
Chou, Yuan I. Scarlet,Kong, Jinge,Song, Rui,et al. Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions[J]. BIOMARKERS,2014,19(8):684-692.
APA Chou, Yuan I. Scarlet,Kong, Jinge,Song, Rui,Yan, Lulu,Zheng, Lemin,&Zhang, Yongzhen.(2014).Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions.BIOMARKERS,19(8),684-692.
MLA Chou, Yuan I. Scarlet,et al."Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions".BIOMARKERS 19.8(2014):684-692.
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