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学科主题: 临床医学
题名:
Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients
作者: Zhang, Zhi-Chao1; Jin, Feng-Shuo2; Liu, Dong-Ming3; Shen, Zhou-Jun4; Sun, Ying-Hao5; Guo, Ying-Lu1
关键词: chronic bacterial prostatitis ; ciprofloxacin ; levofloxacin ; recurrence
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2012-11-01
DOI: 10.1038/aja.2012.48
卷: 14, 期:6, 页:870-874
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: PELVIC PAIN SYNDROME ; 500 MG ; ANTIBIOTIC-THERAPY ; MULTICENTER ; TRIAL ; MEN
英文摘要:

Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis. We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients. This was a multicenter, open-label, randomized controlled non-inferiority trial. Four hundred and seventy-one patients with clinical symptoms/ signs were enrolled into the study, and 408 patients were microbiologically confirmed chronic bacterial prostatitis, who were randomized to either oral levofloxacin (500 mg q.d.) or ciprofloxacin (500 mg b.i.d.) for 4 weeks. Bacterial clearance rate, clinical symptoms/signs, adverse reactions and disease recurrence were assessed. The clinical symptoms and signs (including dysuria, perineal discomfort or pain) and bacteria cultures in 209 patients treated with levofloxacin and 199 patients treated with ciprofloxacin were similar. The most common bacteria were Escherichia coli and Staphylococcus aureus. One to four weeks after the end of 4 weeks treatment, the bacterial clearance rate (86.06% vs. 60.03%; P<0.05) and the clinical efficacy (including clinical cure and clinical improvement(93.30% vs. 71.86%; P<0.05)) were significantly higher in the levofloxacin-treated group than in the ciprofloxacin-treated group. The microbiological recurrence rate was significantly lower in the levofloxacin-treated group than in the ciprofloxacin-treated group (4.00% vs. 19.25%; P<0.05). Rates of adverse events and treatment-related adverse events were slightly lower in the levofloxacin-treated group than in ciprofloxacin-treated group. Levofloxacin showed some advantages over ciprofloxacin in terms of clinical efficacy and disease recurrence, with a low rate of adverse events, for the treatment of chronic bacterial prostatitis in Chinese patients. Asian Journal of Andrology (2012) 14, 870-874; doi: 10.1038/aja.2012.48; published online 6 August 2012

语种: 英语
项目资助者: Daiichi Sankyo Co., Ltd
WOS记录号: WOS:000310790500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65906
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Urol, Androl Ctr, Beijing 100034, Peoples R China
2.Third Mil Med Univ, Daping Hosp, Chongqing 400042, Peoples R China
3.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai 200001, Peoples R China
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai 200025, Peoples R China
5.Second Mil Med Univ, Changhai Hosp, Shanghai 200433, Peoples R China

Recommended Citation:
Zhang, Zhi-Chao,Jin, Feng-Shuo,Liu, Dong-Ming,et al. Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients[J]. ASIAN JOURNAL OF ANDROLOGY,2012,14(6):870-874.
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