北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Local transplantation of osteogenic pre-differentiated autologous adipose-derived mesenchymal stem cells may accelerate non-union fracture healing with limited pro-metastatic potency
作者: Han, Duanyang; Han, Na; Zhang, Peixun; Jiang, Baoguo
关键词: ADSC ; pre-differentiation ; fracture non-union ; pro-metastatic
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:1, 页:1406-1410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: BONE-MARROW ; TIBIAL FRACTURES ; NON-UNION ; TISSUE ; REGENERATION ; PROGENITORS ; LINEAGE ; VIVO
英文摘要:

Fracture non-union is a serious complication in orthopedic clinical practice. Mesenchymal stem cells are believed to play a vital role in fracture healing process. Among various origins of mesenchymal stem cell, adipose derived stem cells hold great promise especially in clinical milieu. However, the wide spread application of mesenchymal stem cell based therapy is impeded by the pro-metastasis nature of the mesenchymal stem cell itself. Based on the findings from previous studies, we hypothesize that local transplanted osteogenic pre-differentiatiated adipose stem cell may promote the non-union fracture healing. Moreover, the pre-differnetiation stem cells by downregulating the expression of CCL5 and CCL2. This novel osteogenic pre-differnetiation technique may help clinical orthopedists to resolve the refractory non-union cases and shed new light on other stem cell based therapies to counteract to avoid the pro-metastasis nature of the mesenchymal stem cells.

语种: 英语
所属项目编号: 2014CB542200 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 31471144 ; 30971526 ; 31100860 ; 31040043 ; 31371210 ; 8137-2044 ; BMU20110270 ; 7142164
项目资助者: Chinese National Ministry of Science and Technology 973 Project Planning ; ministry of education innovation team ; National Natural Science Fund ; Educational Ministry New Century Excellent Talents Support Project ; Beijing Natural Science Foundation
WOS记录号: WOS:000349897200179
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65907
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing 100871, Peoples R China

Recommended Citation:
Han, Duanyang,Han, Na,Zhang, Peixun,et al. Local transplantation of osteogenic pre-differentiated autologous adipose-derived mesenchymal stem cells may accelerate non-union fracture healing with limited pro-metastatic potency[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(1):1406-1410.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, Duanyang]'s Articles
[Han, Na]'s Articles
[Zhang, Peixun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, Duanyang]‘s Articles
[Han, Na]‘s Articles
[Zhang, Peixun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace