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学科主题临床医学
Local transplantation of osteogenic pre-differentiated autologous adipose-derived mesenchymal stem cells may accelerate non-union fracture healing with limited pro-metastatic potency
Han, Duanyang; Han, Na; Zhang, Peixun; Jiang, Baoguo
关键词ADSC pre-differentiation fracture non-union pro-metastatic
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015
8期:1页:1406-1410
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]BONE-MARROW ; TIBIAL FRACTURES ; NON-UNION ; TISSUE ; REGENERATION ; PROGENITORS ; LINEAGE ; VIVO
英文摘要

Fracture non-union is a serious complication in orthopedic clinical practice. Mesenchymal stem cells are believed to play a vital role in fracture healing process. Among various origins of mesenchymal stem cell, adipose derived stem cells hold great promise especially in clinical milieu. However, the wide spread application of mesenchymal stem cell based therapy is impeded by the pro-metastasis nature of the mesenchymal stem cell itself. Based on the findings from previous studies, we hypothesize that local transplanted osteogenic pre-differentiatiated adipose stem cell may promote the non-union fracture healing. Moreover, the pre-differnetiation stem cells by downregulating the expression of CCL5 and CCL2. This novel osteogenic pre-differnetiation technique may help clinical orthopedists to resolve the refractory non-union cases and shed new light on other stem cell based therapies to counteract to avoid the pro-metastasis nature of the mesenchymal stem cells.

语种英语
WOS记录号WOS:000349897200179
项目编号2014CB542200 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 31471144 ; 30971526 ; 31100860 ; 31040043 ; 31371210 ; 8137-2044 ; BMU20110270 ; 7142164
资助机构Chinese National Ministry of Science and Technology 973 Project Planning ; ministry of education innovation team ; National Natural Science Fund ; Educational Ministry New Century Excellent Talents Support Project ; Beijing Natural Science Foundation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65907
专题北京大学第二临床医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Han, Duanyang,Han, Na,Zhang, Peixun,et al. Local transplantation of osteogenic pre-differentiated autologous adipose-derived mesenchymal stem cells may accelerate non-union fracture healing with limited pro-metastatic potency[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(1):1406-1410.
APA Han, Duanyang,Han, Na,Zhang, Peixun,&Jiang, Baoguo.(2015).Local transplantation of osteogenic pre-differentiated autologous adipose-derived mesenchymal stem cells may accelerate non-union fracture healing with limited pro-metastatic potency.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8(1),1406-1410.
MLA Han, Duanyang,et al."Local transplantation of osteogenic pre-differentiated autologous adipose-derived mesenchymal stem cells may accelerate non-union fracture healing with limited pro-metastatic potency".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8.1(2015):1406-1410.
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