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Effects of Glial Cell Line-Derived Neurotrophic Factor Intrathecal Injection on Spinal Dorsal Horn Glial Fibrillary Acidic Protein Expression in a Rat Model of Neuropathic Pain
Guo, Jianrong1; Jia, Donglin2; Jin, Baowei3; Xu, Feng3; Yuan, Xiaohong3; Shen, Huachun3
关键词astrocytic marker central nervous system spinal dorsal horn spinal nerve ligation
刊名INTERNATIONAL JOURNAL OF NEUROSCIENCE
2012-07-01
DOI10.3109/00207454.2012.672500
122期:7页:388-394
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MECHANICAL ALLODYNIA ; PATHOLOGICAL PAIN ; SENSORY NEURONS ; NERVE LIGATION ; ACTIVATION ; GDNF ; CONTRIBUTES ; INVOLVEMENT ; BEHAVIOR ; INJURY
英文摘要

Glial fibrillary acidic protein (GFAP) is a specific astrocytic marker in the central nervous system. Few studies on the effects of glial cell line-derived neurotrophic factor (GDNF) intrathecal injection on GFAP expression exist in the literature. The present study determined GFAP expression in rat spinal dorsal horn following a spinal nerve ligation (SNL). The effects of GDNF intrathecal injection on GFAP expression were examined to gather experimental evidence on the mechanisms underlying neuropathic pain. Following L5-6 SNL, male Sprague-Dawley rats were randomly divided into four groups: normal control, sham-operated, SNL, and GDNF. Each group was further divided into three subgroups (n = 10) according to the times of sacrifice: 3, 7, and 14 days after surgery. Compared with the normal control and the sham-operated groups, GFAP expression in the SNL group increased at day 3 after surgery and lasted until 14 days after. GFAP expression was significantly less in the GDNF group compared with the SNL group which lasted until 14 days after surgery, suggesting that rat spinal dorsal horn GFAP expression contributes to SNL-induced neuropathic pain. The mechanisms underlying GDNF alleviation of neuropathic pain were shown to be related to the GDNF inhibition of GFAP expression in the spinal dorsal horn.

语种英语
WOS记录号WOS:000305011800010
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65917
专题北京大学第三临床医学院_麻醉科
北京大学第三临床医学院_疼痛科
作者单位1.Gongli Hosp Shanghai Pudong New Dist, Dept Anesthesiol, Shanghai 200135, Peoples R China
2.Peking Univ, Dept Anesthesiol, Hosp 3, Beijing 100871, Peoples R China
3.Ningbo Univ, Affiliated Lihuili Hosp, Coll Med, Dept Anesthesiol, Ningbo, Peoples R China
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GB/T 7714
Guo, Jianrong,Jia, Donglin,Jin, Baowei,et al. Effects of Glial Cell Line-Derived Neurotrophic Factor Intrathecal Injection on Spinal Dorsal Horn Glial Fibrillary Acidic Protein Expression in a Rat Model of Neuropathic Pain[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE,2012,122(7):388-394.
APA Guo, Jianrong,Jia, Donglin,Jin, Baowei,Xu, Feng,Yuan, Xiaohong,&Shen, Huachun.(2012).Effects of Glial Cell Line-Derived Neurotrophic Factor Intrathecal Injection on Spinal Dorsal Horn Glial Fibrillary Acidic Protein Expression in a Rat Model of Neuropathic Pain.INTERNATIONAL JOURNAL OF NEUROSCIENCE,122(7),388-394.
MLA Guo, Jianrong,et al."Effects of Glial Cell Line-Derived Neurotrophic Factor Intrathecal Injection on Spinal Dorsal Horn Glial Fibrillary Acidic Protein Expression in a Rat Model of Neuropathic Pain".INTERNATIONAL JOURNAL OF NEUROSCIENCE 122.7(2012):388-394.
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