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学科主题: 临床医学
题名:
Effects of Glial Cell Line-Derived Neurotrophic Factor Intrathecal Injection on Spinal Dorsal Horn Glial Fibrillary Acidic Protein Expression in a Rat Model of Neuropathic Pain
作者: Guo, Jianrong1; Jia, Donglin2; Jin, Baowei3; Xu, Feng3; Yuan, Xiaohong3; Shen, Huachun3
关键词: astrocytic marker ; central nervous system ; spinal dorsal horn ; spinal nerve ligation
刊名: INTERNATIONAL JOURNAL OF NEUROSCIENCE
发表日期: 2012-07-01
DOI: 10.3109/00207454.2012.672500
卷: 122, 期:7, 页:388-394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MECHANICAL ALLODYNIA ; PATHOLOGICAL PAIN ; SENSORY NEURONS ; NERVE LIGATION ; ACTIVATION ; GDNF ; CONTRIBUTES ; INVOLVEMENT ; BEHAVIOR ; INJURY
英文摘要:

Glial fibrillary acidic protein (GFAP) is a specific astrocytic marker in the central nervous system. Few studies on the effects of glial cell line-derived neurotrophic factor (GDNF) intrathecal injection on GFAP expression exist in the literature. The present study determined GFAP expression in rat spinal dorsal horn following a spinal nerve ligation (SNL). The effects of GDNF intrathecal injection on GFAP expression were examined to gather experimental evidence on the mechanisms underlying neuropathic pain. Following L5-6 SNL, male Sprague-Dawley rats were randomly divided into four groups: normal control, sham-operated, SNL, and GDNF. Each group was further divided into three subgroups (n = 10) according to the times of sacrifice: 3, 7, and 14 days after surgery. Compared with the normal control and the sham-operated groups, GFAP expression in the SNL group increased at day 3 after surgery and lasted until 14 days after. GFAP expression was significantly less in the GDNF group compared with the SNL group which lasted until 14 days after surgery, suggesting that rat spinal dorsal horn GFAP expression contributes to SNL-induced neuropathic pain. The mechanisms underlying GDNF alleviation of neuropathic pain were shown to be related to the GDNF inhibition of GFAP expression in the spinal dorsal horn.

语种: 英语
WOS记录号: WOS:000305011800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65917
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Gongli Hosp Shanghai Pudong New Dist, Dept Anesthesiol, Shanghai 200135, Peoples R China
2.Peking Univ, Dept Anesthesiol, Hosp 3, Beijing 100871, Peoples R China
3.Ningbo Univ, Affiliated Lihuili Hosp, Coll Med, Dept Anesthesiol, Ningbo, Peoples R China

Recommended Citation:
Guo, Jianrong,Jia, Donglin,Jin, Baowei,et al. Effects of Glial Cell Line-Derived Neurotrophic Factor Intrathecal Injection on Spinal Dorsal Horn Glial Fibrillary Acidic Protein Expression in a Rat Model of Neuropathic Pain[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE,2012,122(7):388-394.
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