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学科主题: 临床医学
题名:
Meta-Analysis of the Effect of Intravitreal Bevacizumab in Branch Retinal Vein Occlusion
作者: Zhu, Dan1; Jin, Zi Ye1; Tao, Yong2,3; Jonas, Jost B.4
刊名: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
发表日期: 2013-07-01
DOI: 10.1089/jop.2012.0278
卷: 29, 期:6, 页:523-529
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology ; Pharmacology & Pharmacy
研究领域[WOS]: Ophthalmology ; Pharmacology & Pharmacy
关键词[WOS]: MACULAR EDEMA SECONDARY ; TRIAMCINOLONE ACETONIDE ; RANIBIZUMAB
英文摘要:

Background: To further evaluate the effect of intravitreal bevacizumab (IVB) for the treatment of branch retinal vein occlusion in a meta-analysis of previous studies.

Methods: Pertinent publications were identified through systemic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register up to July 2012. Data on central macular thickness and best-corrected visual acuity obtained at 4 and 12 weeks after treatment were extracted. Groups of patients receiving IVB were compared with control groups.

Results: Four randomized controlled and 3 comparative studies were included. A publication bias was not detected by funnel plots, the Egger method, or the Begg method. Best corrected visual acuity measured at 4 and 12 weeks after baseline increased significantly in the IVB groups as compared with the control groups [4 weeks: weighted mean deviation (WMD) = -0.09; 95% confidence interval (CI): -0.12, -0.05; P < 0.001; at 12 weeks: WMD = -0.21; 95% CI: -0.30, -0.12; P < 0.001]. Similarly, reduction in central macular thickness at 12 weeks after baseline was significantly higher in the IVB groups than in the control groups (WMD = -29.02; 95% CI: -50.56, -7.49; P = 0.008). The change in central macular thickness at 4 weeks after baseline did not vary significantly between the IVB groups and control groups (WMD = -20.48; 95% CI: -67.30, 26.34; P = 0.39). All included studies taken separately reported on a significant increase in visual acuity in the IVB groups.

Conclusions: Patients with branch retinal vein occlusion experienced a significant benefit in terms of visual improvement and reduction in central macular thickness after the intravitreal injection of bevacizumab.

语种: 英语
所属项目编号: 2009B04
项目资助者: Beijing Novel Program
WOS记录号: WOS:000321616400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65918
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Inner Mongolia Med Coll, Affiliated Hosp, Hohhot, Inner Mongolia, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
3.Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
4.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China

Recommended Citation:
Zhu, Dan,Jin, Zi Ye,Tao, Yong,et al. Meta-Analysis of the Effect of Intravitreal Bevacizumab in Branch Retinal Vein Occlusion[J]. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,2013,29(6):523-529.
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