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学科主题: 药学
题名:
Phospholipid deformable vesicles for buccal delivery of insulin
作者: Yang, TZ; Wang, XT; Yan, XY; Zhang, Q
关键词: insulin ; deformable vesicle ; buccal delivery ; relative pharmacological bioavailability ; relative bioavailability
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2002-06-01
卷: 50, 期:6, 页:749-753
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: IN-VIVO ; DRUG ABSORPTION ; PEPTIDASE ACTIVITIES ; MUCOSA INVITRO ; DIABETIC RATS ; BILE-SALTS ; LIPOSOMES ; TRANSPORT ; RABBIT ; VITRO
英文摘要:

To investigate the possibility of the enhancing effect of deformable vesicles on buccal delivery of insulin, two kinds of vesicles with and without the presence of sodium deoxycholate (deformable vesicles and conventional vesicles) were prepared by reverse phase evaporation methods. The liposomal entrapment efficiency was determined by column chromatography. The particle size and morphology of the vesicles were also evaluated. The hypoglycemic effects, insulin concentrations, and residual amounts of insulin deposited in the buccal membrane after buccal administration of insulin vesicles to rabbits were investigated. Compared with subcutaneous administration of insulin solution, the relative pharmacological bioavailability and the relative bioavailability of buccal administration of insulin vesicles were determined. The results showed that the entrapment efficiencies of the deformable and conventional vesicles were 18.87+/-1.78% (n=3) and 22.07+/-2.16% (n=3), respectively. The particle sizes of the deformable and conventional vesicles were 42.5+/-20.5 nm and 59.7+/-33.8 nm, respectively. There were no significant differences in appearance between the two types of vesicle. Compared with subcutaneous administration of insulin solution, the relative pharmacological bioavailability and the relative bioavailability in the insulin-deformable vesicles group were 15.59% and 19.78%, respectively, which were higher than in the conventional insulin vesicles (p<0.05), blank deformable vesicles and insulin mixture groups (p<0.05). Deformable vesicles have an enhancing effect on buccal delivery of insulin and may be a better carrier than conventional vesicles for buccal delivery of protein drugs.

语种: 英语
WOS记录号: WOS:000175915200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65922
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Yang, TZ,Wang, XT,Yan, XY,et al. Phospholipid deformable vesicles for buccal delivery of insulin[J]. CHEMICAL &amp; PHARMACEUTICAL BULLETIN,2002,50(6):749-753.
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