北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科  > 期刊论文
学科主题: 临床医学
题名:
A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese
作者: An, Ping1; Winkler, Cheryl1; Guan, Li2; O′ Brien, Stephen J.; Zeng, Zheng3; HBV Study Consortium
刊名: JOURNAL OF INFECTIOUS DISEASES
发表日期: 2011-04-01
DOI: 10.1093/infdis/jiq154
卷: 203, 期:7, 页:943-947
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]: Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; HBSAG SEROCLEARANCE ; CARRIERS ; ASSOCIATION ; INFECTION
英文摘要:

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

语种: 英语
所属项目编号: HHSN26120080001E
项目资助者: National Cancer Institue, National Institutes of Health ; National Institutes of Health, National Cancer Institute, Center for Cancer Research
WOS记录号: WOS:000288553800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65925
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.NCI, Basic Res Lab, Frederick, MD 21702 USA
2.NCI, Lab Genom Divers, SAIC Frederick, Frederick, MD 21702 USA
3.Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
An, Ping,Winkler, Cheryl,Guan, Li,et al. A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese[J]. JOURNAL OF INFECTIOUS DISEASES,2011,203(7):943-947.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[An, Ping]'s Articles
[Winkler, Cheryl]'s Articles
[Guan, Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[An, Ping]‘s Articles
[Winkler, Cheryl]‘s Articles
[Guan, Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace