IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese
An, Ping1; Winkler, Cheryl1; Guan, Li2; O′ Brien, Stephen J.; Zeng, Zheng3; HBV Study Consortium
刊名JOURNAL OF INFECTIOUS DISEASES
2011-04-01
DOI10.1093/infdis/jiq154
203期:7页:943-947
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; HBSAG SEROCLEARANCE ; CARRIERS ; ASSOCIATION ; INFECTION
英文摘要

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

语种英语
WOS记录号WOS:000288553800009
项目编号HHSN26120080001E
资助机构National Cancer Institue, National Institutes of Health ; National Institutes of Health, National Cancer Institute, Center for Cancer Research
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65925
专题北京大学第一临床医学院_感染疾病科
作者单位1.NCI, Basic Res Lab, Frederick, MD 21702 USA
2.NCI, Lab Genom Divers, SAIC Frederick, Frederick, MD 21702 USA
3.Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
An, Ping,Winkler, Cheryl,Guan, Li,et al. A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese[J]. JOURNAL OF INFECTIOUS DISEASES,2011,203(7):943-947.
APA An, Ping.,Winkler, Cheryl.,Guan, Li.,O&prime.,Brien, Stephen J..,...&HBV Study Consortium.(2011).A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese.JOURNAL OF INFECTIOUS DISEASES,203(7),943-947.
MLA An, Ping,et al."A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese".JOURNAL OF INFECTIOUS DISEASES 203.7(2011):943-947.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[An, Ping]的文章
[Winkler, Cheryl]的文章
[Guan, Li]的文章
百度学术
百度学术中相似的文章
[An, Ping]的文章
[Winkler, Cheryl]的文章
[Guan, Li]的文章
必应学术
必应学术中相似的文章
[An, Ping]的文章
[Winkler, Cheryl]的文章
[Guan, Li]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。