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学科主题: 口腔医学
题名:
In Vitro Growth of Bioactive Nanostructured Apatites via Agar-Gelatin Hybrid Hydrogel
作者: Deng, Yi1,2; Zhao, Xianghui1; Zhou, Yongsheng1; Zhu, Peizhi2,4; Zhang, Li3; Wei, Shicheng1,2
关键词: Carbonated Apatite ; Agar-Gelatin Hydrogel ; Self-Assembly ; Biocompatibility ; Bone Tissue Engineering
刊名: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
发表日期: 2013-12-01
DOI: 10.1166/jbn.2013.1707
卷: 9, 期:12, 页:1972-1983
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Biomaterials
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: NANO-HYDROXYAPATITE ; CARBONATED HYDROXYAPATITE ; OCTACALCIUM PHOSPHATE ; BIOMIMETIC SYNTHESIS ; BONE ; NANOPARTICLES ; COLLAGEN ; MATRIX ; BIOCOMPATIBILITY ; NANOCOMPOSITE
英文摘要:

Biomimetic synthesis of bone-like carbonated apatite with good biocompatibility is a promising strategy for the development of novel biomaterials for bone engineering applications. Most research efforts have been focused on only protein-based or only polysaccharide-based template for synthesis of apatite minerals. To understand the cooperative roles of gelatin and polysaccharide playing in the biomineralization, agar hydrogel, gelatin and agar-gelatin hybrid hydrogel were respectively introduced as mineralization matrix for the in vitro growth of apatite in the study. It was shown that bundle-like carbonated apatite was successfully prepared in agar-gelatin hybrid hydrogel for the first time, through the interaction between apatite and matrix macromolecule under physiological temperature. Moreover, the in vitro biocompatibility of the prepared nanostructured apatite crystals was investigated using CCK-8 assay and alkaline phosphatase activity of osteoblast-like MC3T3-E1. Compared with HA synthesized by traditional method, the obtained apatite in agar-gelatin hybrid hydrogel could provide significantly higher cell viability and alkaline phosphatase activity. Through the study, we could better understand the role of gelatin and polysaccharide in bone formation process, and the product is a promising candidate to be used in bone tissue engineering.

语种: 英语
所属项目编号: 2012CB933902 ; 2007CB936103
项目资助者: State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
WOS记录号: WOS:000324992000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65929
Appears in Collections:北京大学口腔医学院_口腔颌面外科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Prosthodont, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Sichuan Univ, Res Ctr Nanobiomat, Analyt & Testing Ctr, Chengdu 610064, Peoples R China
4.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Recommended Citation:
Deng, Yi,Zhao, Xianghui,Zhou, Yongsheng,et al. In Vitro Growth of Bioactive Nanostructured Apatites via Agar-Gelatin Hybrid Hydrogel[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2013,9(12):1972-1983.
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