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学科主题口腔医学
In Vitro Growth of Bioactive Nanostructured Apatites via Agar-Gelatin Hybrid Hydrogel
Deng, Yi1,2; Zhao, Xianghui1; Zhou, Yongsheng1; Zhu, Peizhi2,4; Zhang, Li3; Wei, Shicheng1,2
关键词Carbonated Apatite Agar-Gelatin Hydrogel Self-Assembly Biocompatibility Bone Tissue Engineering
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2013-12-01
DOI10.1166/jbn.2013.1707
9期:12页:1972-1983
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Biomaterials
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]NANO-HYDROXYAPATITE ; CARBONATED HYDROXYAPATITE ; OCTACALCIUM PHOSPHATE ; BIOMIMETIC SYNTHESIS ; BONE ; NANOPARTICLES ; COLLAGEN ; MATRIX ; BIOCOMPATIBILITY ; NANOCOMPOSITE
英文摘要

Biomimetic synthesis of bone-like carbonated apatite with good biocompatibility is a promising strategy for the development of novel biomaterials for bone engineering applications. Most research efforts have been focused on only protein-based or only polysaccharide-based template for synthesis of apatite minerals. To understand the cooperative roles of gelatin and polysaccharide playing in the biomineralization, agar hydrogel, gelatin and agar-gelatin hybrid hydrogel were respectively introduced as mineralization matrix for the in vitro growth of apatite in the study. It was shown that bundle-like carbonated apatite was successfully prepared in agar-gelatin hybrid hydrogel for the first time, through the interaction between apatite and matrix macromolecule under physiological temperature. Moreover, the in vitro biocompatibility of the prepared nanostructured apatite crystals was investigated using CCK-8 assay and alkaline phosphatase activity of osteoblast-like MC3T3-E1. Compared with HA synthesized by traditional method, the obtained apatite in agar-gelatin hybrid hydrogel could provide significantly higher cell viability and alkaline phosphatase activity. Through the study, we could better understand the role of gelatin and polysaccharide in bone formation process, and the product is a promising candidate to be used in bone tissue engineering.

语种英语
所属项目编号2012CB933902 ; 2007CB936103
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
WOS记录号WOS:000324992000003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65929
专题北京大学口腔医学院_口腔颌面外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Prosthodont, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Sichuan Univ, Res Ctr Nanobiomat, Analyt & Testing Ctr, Chengdu 610064, Peoples R China
4.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Deng, Yi,Zhao, Xianghui,Zhou, Yongsheng,et al. In Vitro Growth of Bioactive Nanostructured Apatites via Agar-Gelatin Hybrid Hydrogel[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2013,9(12):1972-1983.
APA Deng, Yi,Zhao, Xianghui,Zhou, Yongsheng,Zhu, Peizhi,Zhang, Li,&Wei, Shicheng.(2013).In Vitro Growth of Bioactive Nanostructured Apatites via Agar-Gelatin Hybrid Hydrogel.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,9(12),1972-1983.
MLA Deng, Yi,et al."In Vitro Growth of Bioactive Nanostructured Apatites via Agar-Gelatin Hybrid Hydrogel".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 9.12(2013):1972-1983.
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