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学科主题: 精神卫生
题名:
Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls
作者: Wang, Huali; Golob, Edward J.; Su, Min-Ying
关键词: blood-brain barrier (BBB) ; BBB permeability ; cerebrovascular abnormality ; dynamic contrast enhanced MRI ; mild cognitive impairment ; vascular volume
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2006-09-01
DOI: 10.1002/jmri.20669
卷: 24, 期:3, 页:695-700
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: ALZHEIMERS-DISEASE PATIENTS ; CEREBRAL HYPOPERFUSION ; DEMENTIA ; SPECT ; MODEL
英文摘要:

Purpose: To measure the cerebrovascular volume and blood-brain barrier (131313) permeability indices in hippocampus and cerebellum of patients with mild cognitive impairment (MCI) using dynamic contrast-enhanced MRI (DCE-MRI), and compare to that of normal controls.

Materials and Methods: A total of 11 MCI subjects and 11 healthy elderly controls participated in this prospective study. DCE-MRI was performed to measure the contrast enhancement kinetics. The early enhancement percentage (at 50 seconds after injection) was defined as the vascular volume index, and the ratio between the four to five-minute enhancement relative to the 50-second enhancement was defined as the 131313 permeability index.

Results: The enhancement kinetics measured from hippocampus of MCI individuals demonstrated a lower magnitude and slower decay than healthy controls, suggesting that they had a smaller vascular volume (significant in the right side; P < 0.001) and a higher BBB permeability (not reaching significance level). The vascular volume index was significantly correlated with naming ability (P 0.05).

Conclusion: These results suggest that changes in cerebrovasculature may occur in hippocampus of MCI. DCE-MRI may provide a noninvasive means to measure the subtle BBB leakage associated with the cerebrovascular pathology commonly found in Alzheimer′s disease.

语种: 英语
WOS记录号: WOS:000240300800029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65932
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA 92697 USA
2.Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92717 USA
3.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
4.Tulane Univ, Dept Psychol, New Orleans, LA 70118 USA

Recommended Citation:
Wang, Huali,Golob, Edward J.,Su, Min-Ying. Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2006,24(3):695-700.
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