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学科主题临床医学
Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats
Guo, Yan-Tong1; Leng, Xi-Sheng2; Li, Tao2; Zhao, Jing-Ming1; Lin, Xi-Hou1
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-12-01
10期:23页:3419-3423
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: Peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to regulate growth arrest and terminal differentiation of adipocytes and is used clinically as a new class of antidiabetic drugs. Recently, several studies have reported that treatment of cancer cells with PPAR gamma ligands could induce cell differentiation and apoptosis, suggesting a potential application as chemopreventive agents against carcinogenesis. In the present study, 3 different kinds of PPAR. ligands were subjected to the experiments to confirm their suppressive effects on liver carcinogenesis.

METHODS: Three PPAR gamma ligands, pioglitazone (Pio) (200 ppm), rosiglitazone (Rosi) (200 ppm), and troglitazone (Tro) (1 000 ppm) were investigated on the induction of the placental form of rat glutathione S-transferase (rGST P) positive foci, a precancerous lesion of the liver, and liver cancer formation using a diethylnitrosamine-induced liver cancer model in Wistar rats, and dose dependency of a PPAR gamma ligand was also examined.

RESULTS: PPAR gamma ligands reduced the formation of rGST P-positive foci by diethylnitrosamine and induction of liver cancers was also markedly suppressed by a continuous feeding of Pio at 200 ppm.

CONCLUSION: PPAR gamma ligands are potential chemopreventive agents for liver carcinogenesis.

语种英语
WOS记录号WOS:000208099800007
项目编号30371387
资助机构National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65934
专题北京大学第二临床医学院
作者单位1.Peking Univ, Beijing Jishuitan Hosp, Dept Gen Surg, Forth Clin Med Coll, Beijing 100035, Peoples R China
2.Peking Univ, People Hosp, Dept Gen Surg, Beijing 100044, Peoples R China
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GB/T 7714
Guo, Yan-Tong,Leng, Xi-Sheng,Li, Tao,et al. Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(23):3419-3423.
APA Guo, Yan-Tong,Leng, Xi-Sheng,Li, Tao,Zhao, Jing-Ming,&Lin, Xi-Hou.(2004).Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats.WORLD JOURNAL OF GASTROENTEROLOGY,10(23),3419-3423.
MLA Guo, Yan-Tong,et al."Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats".WORLD JOURNAL OF GASTROENTEROLOGY 10.23(2004):3419-3423.
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