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学科主题: 临床医学
题名:
Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats
作者: Guo, Yan-Tong1; Leng, Xi-Sheng2; Li, Tao2; Zhao, Jing-Ming1; Lin, Xi-Hou1
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2004-12-01
卷: 10, 期:23, 页:3419-3423
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: Peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to regulate growth arrest and terminal differentiation of adipocytes and is used clinically as a new class of antidiabetic drugs. Recently, several studies have reported that treatment of cancer cells with PPAR gamma ligands could induce cell differentiation and apoptosis, suggesting a potential application as chemopreventive agents against carcinogenesis. In the present study, 3 different kinds of PPAR. ligands were subjected to the experiments to confirm their suppressive effects on liver carcinogenesis.

METHODS: Three PPAR gamma ligands, pioglitazone (Pio) (200 ppm), rosiglitazone (Rosi) (200 ppm), and troglitazone (Tro) (1 000 ppm) were investigated on the induction of the placental form of rat glutathione S-transferase (rGST P) positive foci, a precancerous lesion of the liver, and liver cancer formation using a diethylnitrosamine-induced liver cancer model in Wistar rats, and dose dependency of a PPAR gamma ligand was also examined.

RESULTS: PPAR gamma ligands reduced the formation of rGST P-positive foci by diethylnitrosamine and induction of liver cancers was also markedly suppressed by a continuous feeding of Pio at 200 ppm.

CONCLUSION: PPAR gamma ligands are potential chemopreventive agents for liver carcinogenesis.

语种: 英语
所属项目编号: 30371387
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000208099800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65934
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Beijing Jishuitan Hosp, Dept Gen Surg, Forth Clin Med Coll, Beijing 100035, Peoples R China
2.Peking Univ, People Hosp, Dept Gen Surg, Beijing 100044, Peoples R China

Recommended Citation:
Guo, Yan-Tong,Leng, Xi-Sheng,Li, Tao,et al. Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(23):3419-3423.
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