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学科主题: 口腔医学
题名:
Paraneoplastic pemphigus characterized by polymorphic oral mucosal manifestations-Report of two cases
作者: Yan, Zhimin1,2; Hua, Hong1; Gao, Yan3
关键词: diagnosis ; direct immunofluorescence ; indirect immunofluorescence ; oral presentation ; paraneoplastic pemphigus
刊名: QUINTESSENCE INTERNATIONAL
发表日期: 2010-09-01
卷: 41, 期:8, 页:689-694
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: NEOPLASIA ; DIAGNOSIS ; DISEASE
英文摘要:

Paraneoplastic pemphigus is a rare autoimmune disease characterized by polymorphous mucocutaneous lesions in association with underlying neoplasia. We report two Chinese patients, one with chronic lymphocytic leukemia and the other with thymoma. Both of them initially presented with severe oral erosion with lichenoid features that resisted all the regular therapy. The routine histology was not typical in both patients, with features of liquefaction degeneration of the basal cell layer and subbasilar lymphocytic infiltration. Important differential diagnoses for the two cases include lichenoid eruption secondary to chemotherapy, pemphigus, and pemphigoid. Immunohistologic testing played an essential role in the diagnoses. Direct immunofluorescence shows both intercellular and basement membrane deposition of immunoreactants. Indirect immunofluorescence using rat bladder as the substrate has been shown to be an inexpensive and reliable diagnostic tool. Our patients′ clinical and immunopathologic features were consistent with a diagnosis of paraneoplastic pemphigus, a special subset of pemphigus. Patients′ conditions were improved after high-dose systemic corticosteroid therapy after underlying malignancies were treated. (Quintessence Int 2010; 41: 689-694)

语种: 英语
WOS记录号: WOS:000281609300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65935
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Oral Med, Sch Stomatol, Beijing 100081, Peoples R China
2.Univ Med & Dent New Jersey, Div Orofacial Pain, Dept Diagnost Sci, New Jersey Dent Sch, Newark, NJ 07103 USA
3.Peking Univ, Dept Oral Pathol, Sch Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Yan, Zhimin,Hua, Hong,Gao, Yan. Paraneoplastic pemphigus characterized by polymorphic oral mucosal manifestations-Report of two cases[J]. QUINTESSENCE INTERNATIONAL,2010,41(8):689-694.
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