IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Specificity of motor axon regeneration: a comparison of recovery following biodegradable conduit small gap tubulization and epineurial neurorrhaphy
Yu, Youlai; Zhang, Peixun; Yin, Xiaofeng; Han, Na; Kou, Yuhui; Jiang, Baoguo
关键词Biodegradable conduit motor axon regeneration femoral nerve small gap tubulization
刊名AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
2015
7期:1页:53-65
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]PERIPHERAL-NERVE REPAIR ; PREFERENTIAL REINNERVATION ; FLUORESCENT TRACERS ; INJURY ; NEURONS ; RAT ; ACCURACY ; PATHWAYS ; MODEL ; TUBES
英文摘要

Functional recovery is often unsatisfactory after lesions in the peripheral nervous system despite the strong potential for regeneration and advances in microsurgical techniques. Axonal regeneration in mixed nerve into inappropriate pathways is a major contributing factor to this failure. In this study, the rat femoral nerve model of transection and surgical repair was used to evaluate the specificity of motor axon regeneration as well as functional and morphological recovery using biodegradable conduit small gap tubulization compared to epineurial neurorrhaphy. 12 weeks after nerve repair, the specificity was assessed using the retrograde neurotracers TB and DiI to backlabel motor neurons that regenerate axons into muscle and cutaneous pathways. To evaluate the functional recovery of the quadriceps muscle, the quadriceps muscle forces were examined. The quadriceps muscle and myelinated axons were assessed using electrophysiology and histology. The results showed that the specificity of motor axon regeneration (preferential reinnervation) was significantly higher when the nerve transection was treated by biodegradable conduit small gap tubulization and there was no significant difference between the two suture methods with respect to the functional and morphological recovery. This study demonstrated that the quicker and easier biodegradable conduit small gap tubulization may get more accurate reinnervation than traditional epineurial neurorrhaphy and produced functional and morphological recovery equal to traditional epineurial neurorrhaphy.

语种英语
WOS记录号WOS:000349843800005
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65938
Collection北京大学第二临床医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Yu, Youlai,Zhang, Peixun,Yin, Xiaofeng,et al. Specificity of motor axon regeneration: a comparison of recovery following biodegradable conduit small gap tubulization and epineurial neurorrhaphy[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2015,7(1):53-65.
APA Yu, Youlai,Zhang, Peixun,Yin, Xiaofeng,Han, Na,Kou, Yuhui,&Jiang, Baoguo.(2015).Specificity of motor axon regeneration: a comparison of recovery following biodegradable conduit small gap tubulization and epineurial neurorrhaphy.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,7(1),53-65.
MLA Yu, Youlai,et al."Specificity of motor axon regeneration: a comparison of recovery following biodegradable conduit small gap tubulization and epineurial neurorrhaphy".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 7.1(2015):53-65.
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