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学科主题临床医学
The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type
Liang, Li1; Zhang, Zhang1; Wang, Ying1; Nong, Lin1; Zheng, Yalin1; Qu, Linlin1; Zhang, Bo2; Li, Ting1
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/435423
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
资助者National Natural Sciences Foundation of China, Beijing ; National Natural Sciences Foundation of China, Beijing
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]TUMOR-SUPPRESSOR GENE ; COMPARATIVE GENOMIC HYBRIDIZATION ; PERIPHERAL T ; LINE ; PRDM1/BLIMP-1 ; MALIGNANCIES ; NEOPLASMS ; LEUKEMIA
英文摘要

6q21 genetic deletion has been frequently detected in extranodal NK/T cell lymphoma, nasal type (EN-NK/T-NT), and PRDM1 is considered as candidate gene. However, direct detection of PRDM1 deletion has not been well documented. We investigated genetic alterations of 6q21 and PRDM1 in 43 cases of EN-NK/T-NT and cell lines by FISH. PRDM1 expression was evaluated by immunohistochemistry and Western blot. The correlation between genetic alteration and PRDM1 expression and the significance in clinic-pathologic were analyzed. Heterozygous deletion of 6q21 and/or PRDM1 was observed in 24 of 43 cases (55.81%) of ENNK/T-NT including 16 cases (37.21%) for 6q21 deletion and 19 cases (44.19%) for PRDM1 deletion. Similarly, heterozygous codeletion of 6q21 and PRDM1 was identified in NK92 and NKL cells. The heterozygous deletion of 6q21 and/or PRDM1 was correlated with PRDM1 expression. However, genetic deletion of 6q21 and/or PRDM1 was not correlated with clinicopathological features of ENNK/T-NT, while PRDM1 expression showed positive effect on the outcome of patients as those as disease site, B symptom, and clinical stage. Thus, heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in EN-NK/T-NT and correlated with downregulation of PRDM1. But the prognostic role of genetic deletion needs to be further evaluated in larger cohort.

语种英语
所属项目编号81470359
资助者National Natural Sciences Foundation of China, Beijing ; National Natural Sciences Foundation of China, Beijing
WOS记录号WOS:000357826600001
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65943
Collection北京大学第一临床医学院_病理科
作者单位1.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Liang, Li,Zhang, Zhang,Wang, Ying,et al. The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Liang, Li.,Zhang, Zhang.,Wang, Ying.,Nong, Lin.,Zheng, Yalin.,...&Li, Ting.(2015).The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type.BIOMED RESEARCH INTERNATIONAL.
MLA Liang, Li,et al."The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type".BIOMED RESEARCH INTERNATIONAL (2015).
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