IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy
Wang, Ji-Guang1; Zeng, Wei-Fang1; He, Yu-Song2; Chen, Liang-Long3; Wei, Meng4; Li, Zhao-Ping5; Zhang, Bao-Wei6; Li, Yan1; EXAM Investigators
关键词Angiotensin receptor blocker Calcium channel blocker Hypertension Single-pill combination Randomized controlled trial
刊名ADVANCES IN THERAPY
2013-08-01
DOI10.1007/s12325-013-0048-x
30期:8页:771-783
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
资助者Novartis Pharma AG (Basel, Switzerland) ; Novartis Pharma AG (Basel, Switzerland)
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]SINGLE-PILL COMBINATION ; FIXED-DOSE COMBINATION ; BLOOD-PRESSURE ; RANDOMIZED-TRIAL ; CHANNEL BLOCKER ; AMLODIPINE ; PREVENTION ; VALSARTAN ; EFFICACY ; OUTCOMES
英文摘要

Current hypertension guidelines recommend single-pill combinations because they not only improve convenience and compliance to therapy and thus blood pressure (BP) control, but also reduce health-care costs. This study compared the efficacy and safety of valsartan/amlodipine single-pill combination with nifedipine gastrointestinal therapeutic system (GITS) in Chinese patients with hypertension who were inadequately controlled with monotherapy.

In this multicenter, open-label, active-controlled, parallel-group study, 564 patients with hypertension not adequately controlled by prior monotherapy were randomized to receive valsartan/amlodipine 80/5 mg or nifedipine GITS 30 mg once daily for 12 weeks.

In the intention-to-treat analysis (n = 540), valsartan/amlodipine (n = 272) showed a least-square mean reduction of -16.6 versus -10.8 mmHg by nifedipine GITS (n = 268; mean between-treatment difference: -5.8 mmHg; P < 0.0001) from baseline to week 12. The corresponding results for mean sitting diastolic BP were -8.6 and -4.6 mmHg, respectively (difference: -4.0 mmHg; P < 0.0001). The percentage of patients achieving the BP target (< 140/90 or < 130/80 mmHg in the absence or presence of diabetes mellitus, respectively) was significantly higher with valsartan/amlodipine (79.0%) versus nifedipine GITS (57.4%; P < 0.0001). The overall incidence rate of adverse events was lower with valsartan/amlodipine (19.2%) than with nifedipine GITS (29.4%; P = 0.004).

The valsartan/amlodipine 80/5 mg single-pill combination is well tolerated and more effective than nifedipine GITS 30 mg for BP control in Chinese patients with hypertension.

语种英语
资助者Novartis Pharma AG (Basel, Switzerland) ; Novartis Pharma AG (Basel, Switzerland)
WOS记录号WOS:000324325400005
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65944
Collection北京大学第一临床医学院_心血管内科
作者单位1.Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Shanghai Key Lab Hypertens, Shanghai Inst Hypertens,Ruijin Hosp,Sch Med, Shanghai, Peoples R China
2.Novartis Pharmaceut, Beijing, Peoples R China
3.Fujian Med Univ, Prov Inst Coronary Artery Dis, Affiliated Union Hosp, Dept Cardiol, Fuzhou, Peoples R China
4.Shanghai Sixth Peoples Hosp, Dept Cardiol, Shanghai, Peoples R China
5.Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Minist Hlth, Dept Cardiol,Hosp 3, Beijing 100871, Peoples R China
6.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ji-Guang,Zeng, Wei-Fang,He, Yu-Song,et al. Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy[J]. ADVANCES IN THERAPY,2013,30(8):771-783.
APA Wang, Ji-Guang.,Zeng, Wei-Fang.,He, Yu-Song.,Chen, Liang-Long.,Wei, Meng.,...&EXAM Investigators.(2013).Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy.ADVANCES IN THERAPY,30(8),771-783.
MLA Wang, Ji-Guang,et al."Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy".ADVANCES IN THERAPY 30.8(2013):771-783.
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