北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy
作者: Wang, Ji-Guang1; Zeng, Wei-Fang1; He, Yu-Song2; Chen, Liang-Long3; Wei, Meng4; Li, Zhao-Ping5; Zhang, Bao-Wei6; Li, Yan1; EXAM Investigators
关键词: Angiotensin receptor blocker ; Calcium channel blocker ; Hypertension ; Single-pill combination ; Randomized controlled trial
刊名: ADVANCES IN THERAPY
发表日期: 2013-08-01
DOI: 10.1007/s12325-013-0048-x
卷: 30, 期:8, 页:771-783
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: SINGLE-PILL COMBINATION ; FIXED-DOSE COMBINATION ; BLOOD-PRESSURE ; RANDOMIZED-TRIAL ; CHANNEL BLOCKER ; AMLODIPINE ; PREVENTION ; VALSARTAN ; EFFICACY ; OUTCOMES
英文摘要:

Current hypertension guidelines recommend single-pill combinations because they not only improve convenience and compliance to therapy and thus blood pressure (BP) control, but also reduce health-care costs. This study compared the efficacy and safety of valsartan/amlodipine single-pill combination with nifedipine gastrointestinal therapeutic system (GITS) in Chinese patients with hypertension who were inadequately controlled with monotherapy.

In this multicenter, open-label, active-controlled, parallel-group study, 564 patients with hypertension not adequately controlled by prior monotherapy were randomized to receive valsartan/amlodipine 80/5 mg or nifedipine GITS 30 mg once daily for 12 weeks.

In the intention-to-treat analysis (n = 540), valsartan/amlodipine (n = 272) showed a least-square mean reduction of -16.6 versus -10.8 mmHg by nifedipine GITS (n = 268; mean between-treatment difference: -5.8 mmHg; P < 0.0001) from baseline to week 12. The corresponding results for mean sitting diastolic BP were -8.6 and -4.6 mmHg, respectively (difference: -4.0 mmHg; P < 0.0001). The percentage of patients achieving the BP target (< 140/90 or < 130/80 mmHg in the absence or presence of diabetes mellitus, respectively) was significantly higher with valsartan/amlodipine (79.0%) versus nifedipine GITS (57.4%; P < 0.0001). The overall incidence rate of adverse events was lower with valsartan/amlodipine (19.2%) than with nifedipine GITS (29.4%; P = 0.004).

The valsartan/amlodipine 80/5 mg single-pill combination is well tolerated and more effective than nifedipine GITS 30 mg for BP control in Chinese patients with hypertension.

语种: 英语
项目资助者: Novartis Pharma AG (Basel, Switzerland)
WOS记录号: WOS:000324325400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65944
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Shanghai Key Lab Hypertens, Shanghai Inst Hypertens,Ruijin Hosp,Sch Med, Shanghai, Peoples R China
2.Novartis Pharmaceut, Beijing, Peoples R China
3.Fujian Med Univ, Prov Inst Coronary Artery Dis, Affiliated Union Hosp, Dept Cardiol, Fuzhou, Peoples R China
4.Shanghai Sixth Peoples Hosp, Dept Cardiol, Shanghai, Peoples R China
5.Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Minist Hlth, Dept Cardiol,Hosp 3, Beijing 100871, Peoples R China
6.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Ji-Guang,Zeng, Wei-Fang,He, Yu-Song,et al. Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy[J]. ADVANCES IN THERAPY,2013,30(8):771-783.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Ji-Guang]'s Articles
[Zeng, Wei-Fang]'s Articles
[He, Yu-Song]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Ji-Guang]‘s Articles
[Zeng, Wei-Fang]‘s Articles
[He, Yu-Song]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace