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IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Effect of Abnormal Fasting Plasma Glucose Level on All-Cause Mortality in Older Patients With Acute Myocardial Infarction: Results From the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS)
作者: Yang, Shi-Wei1; Zhou, Yu-Jie1; Nie, Xiao-Min1; Liu, Yu-Yang1; Du, Jie1; Hu, Da-Yi2; Jia, De-An1; Gao, Fei1; Hu, Bin1; Fang, Zhe1; Han, Hong-Ya1; Liu, Xiao-Li1; Yan, Zhen-Xian1; Wang, Jian-Long1; Hua, Qi3; Shi, Yu-Jie4; Li, Hong-Wei5; BEAMIS Study Grp
刊名: MAYO CLINIC PROCEEDINGS
发表日期: 2011-02-01
DOI: 10.4065/mcp.2010.0473
卷: 86, 期:2, 页:94-104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ACUTE CORONARY SYNDROMES ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; CARDIOVASCULAR-DISEASE ; UNITED-STATES ; RISK-FACTOR ; SHORT-TERM ; US ADULTS ; HYPERGLYCEMIA ; HYPOGLYCEMIA
英文摘要:

OBJECTIVE: To assess whether the relationship between abnormal fasting plasma glucose (FPG) levels and patient outcomes holds for both older men and older women with acute myocardial infarction (AMI).

PATIENTS AND METHODS: From April 1, 2004, to October 31, 2006, a total of 2016 consecutive older patients (age >= 65 years) presenting with AMI were screened. Of these patients, 1854 were consecutively enrolled in the study. Patients were categorized into 4 groups: the hypoglycemic group (FPG, <= 90.0 mg/dL [to convert to mmol/L, multiply by 0.0555]; n=443, 23.9%), the euglycemic group (FPG, 90.1-126.0 mg/dL; n=812, 43.8%), the mildly hyperglycemic group (FPG, 126.1-162.0 mg/dL; n=308, 16.6%), and the severely hyperglycemic group (FPG, >= 162.1 mg/dL; n=291, 15.7%). The primary outcomes were rates of in-hospital and 3-year mortality.

RESULTS: Female patients were older and had a higher incidence of diabetes mellitus but lower rates of smoking and use of invasive therapy. Men tended to have a higher frequency of hypoglycemia, whereas women tended to have a higher frequency of hyperglycemia. No significant difference was found in in-hospital (10.9% vs 9.1%; P=.36) or 3-year (24.5% vs 24.5%; P=.99) mortality between male and female patients, and FPG-associated mortality did not vary significantly by sex.

CONCLUSION: An increased FPG level was associated with a relatively higher risk of in-hospital mortality in men but not in women. Nonetheless, increased and decreased FPG levels at admission could predict higher mortality rates regardless of sex. There was a striking U-shaped relationship between FPG levels and in-hospital and 3-year mortality. The effect of abnormal FPG level on outcomes among older patients with AMI did not vary significantly by sex.

语种: 英语
所属项目编号: Z0005190042811
项目资助者: Beijing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000287460600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65963
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
2.Gen Hosp Beijing Mil, Dept Cardiol, Beijing, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Xuanwu Hosp, Dept Cardiol, Beijing 100029, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China

Recommended Citation:
Yang, Shi-Wei,Zhou, Yu-Jie,Nie, Xiao-Min,et al. Effect of Abnormal Fasting Plasma Glucose Level on All-Cause Mortality in Older Patients With Acute Myocardial Infarction: Results From the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS)[J]. MAYO CLINIC PROCEEDINGS,2011,86(2):94-104.
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