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Effect of Abnormal Fasting Plasma Glucose Level on All-Cause Mortality in Older Patients With Acute Myocardial Infarction: Results From the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS)
Yang, Shi-Wei1; Zhou, Yu-Jie1; Nie, Xiao-Min1; Liu, Yu-Yang1; Du, Jie1; Hu, Da-Yi2; Jia, De-An1; Gao, Fei1; Hu, Bin1; Fang, Zhe1; Han, Hong-Ya1; Liu, Xiao-Li1; Yan, Zhen-Xian1; Wang, Jian-Long1; Hua, Qi3; Shi, Yu-Jie4; Li, Hong-Wei5; BEAMIS Study Grp
刊名MAYO CLINIC PROCEEDINGS
2011-02-01
DOI10.4065/mcp.2010.0473
86期:2页:94-104
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ACUTE CORONARY SYNDROMES ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; CARDIOVASCULAR-DISEASE ; UNITED-STATES ; RISK-FACTOR ; SHORT-TERM ; US ADULTS ; HYPERGLYCEMIA ; HYPOGLYCEMIA
英文摘要

OBJECTIVE: To assess whether the relationship between abnormal fasting plasma glucose (FPG) levels and patient outcomes holds for both older men and older women with acute myocardial infarction (AMI).

PATIENTS AND METHODS: From April 1, 2004, to October 31, 2006, a total of 2016 consecutive older patients (age >= 65 years) presenting with AMI were screened. Of these patients, 1854 were consecutively enrolled in the study. Patients were categorized into 4 groups: the hypoglycemic group (FPG, <= 90.0 mg/dL [to convert to mmol/L, multiply by 0.0555]; n=443, 23.9%), the euglycemic group (FPG, 90.1-126.0 mg/dL; n=812, 43.8%), the mildly hyperglycemic group (FPG, 126.1-162.0 mg/dL; n=308, 16.6%), and the severely hyperglycemic group (FPG, >= 162.1 mg/dL; n=291, 15.7%). The primary outcomes were rates of in-hospital and 3-year mortality.

RESULTS: Female patients were older and had a higher incidence of diabetes mellitus but lower rates of smoking and use of invasive therapy. Men tended to have a higher frequency of hypoglycemia, whereas women tended to have a higher frequency of hyperglycemia. No significant difference was found in in-hospital (10.9% vs 9.1%; P=.36) or 3-year (24.5% vs 24.5%; P=.99) mortality between male and female patients, and FPG-associated mortality did not vary significantly by sex.

CONCLUSION: An increased FPG level was associated with a relatively higher risk of in-hospital mortality in men but not in women. Nonetheless, increased and decreased FPG levels at admission could predict higher mortality rates regardless of sex. There was a striking U-shaped relationship between FPG levels and in-hospital and 3-year mortality. The effect of abnormal FPG level on outcomes among older patients with AMI did not vary significantly by sex.

语种英语
WOS记录号WOS:000287460600004
项目编号Z0005190042811
资助机构Beijing Municipal Science &amp ; Technology Commission
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65963
专题北京大学第二临床医学院_心血管内科
作者单位1.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
2.Gen Hosp Beijing Mil, Dept Cardiol, Beijing, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Xuanwu Hosp, Dept Cardiol, Beijing 100029, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Yang, Shi-Wei,Zhou, Yu-Jie,Nie, Xiao-Min,et al. Effect of Abnormal Fasting Plasma Glucose Level on All-Cause Mortality in Older Patients With Acute Myocardial Infarction: Results From the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS)[J]. MAYO CLINIC PROCEEDINGS,2011,86(2):94-104.
APA Yang, Shi-Wei.,Zhou, Yu-Jie.,Nie, Xiao-Min.,Liu, Yu-Yang.,Du, Jie.,...&BEAMIS Study Grp.(2011).Effect of Abnormal Fasting Plasma Glucose Level on All-Cause Mortality in Older Patients With Acute Myocardial Infarction: Results From the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS).MAYO CLINIC PROCEEDINGS,86(2),94-104.
MLA Yang, Shi-Wei,et al."Effect of Abnormal Fasting Plasma Glucose Level on All-Cause Mortality in Older Patients With Acute Myocardial Infarction: Results From the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS)".MAYO CLINIC PROCEEDINGS 86.2(2011):94-104.
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