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Direct current stimulation over the human sensorimotor cortex modulates the brain′s hemodynamic response to tactile stimulation
Wang, Ye1; Hao, Ying1; Zhou, Junhong1; Fried, Peter J.2,3,4; Wang, Xiaoying1,5; Zhang, Jue1,6; Fang, Jing1,6; Pascual-Leone, Alvaro2,3,4; Manor, Brad2,3,4,7
关键词sensorimotor cortex tactile stimuli tDCS
刊名EUROPEAN JOURNAL OF NEUROSCIENCE
2015-08-01
DOI10.1111/ejn.12953
42期:3页:1933-1940
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; Sidney Baer Foundation ; KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst/The Harvard Clinical and Translational Science Center ; K01 award from the National Institute on Aging ; National Natural Science Foundation of China ; Sidney Baer Foundation ; KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst/The Harvard Clinical and Translational Science Center ; K01 award from the National Institute on Aging
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SOMATOSENSORY CORTEX ; POLARIZING CURRENTS ; EVOKED-POTENTIALS ; CEREBRAL CORTEX ; FMRI ; AMPLITUDE ; TDCS ; REPRESENTATIONS ; RECOGNITION ; INFORMATION
英文摘要

Tactile stimuli produce afferent signals that activate specific regions of the cerebral cortex. Noninvasive transcranial direct current stimulation (tDCS) effectively modulates cortical excitability. We therefore hypothesised that a single session of tDCS targeting the sensory cortices would alter the cortical response to tactile stimuli. This hypothesis was tested with a block-design functional magnetic resonance imaging protocol designed to quantify the blood oxygen level-dependent response to controlled sinusoidal pressure stimulation applied to the right foot sole, as compared with rest, in 16 healthy young adults. Following sham tDCS, right foot sole stimulation was associated with activation bilaterally within the precentral cortex, postcentral cortex, middle and superior frontal gyri, temporal lobe (subgyral) and cingulate gyrus. Activation was also observed in the left insula, middle temporal lobe, superior parietal lobule, supramarginal gyrus and thalamus, as well as the right inferior parietal lobule and claustrum (false discovery rate corrected, P<0.05). To explore the regional effects of tDCS, brain regions related to somatosensory processing, and cortical areas underneath each tDCS electrode, were chosen as regions of interest. Real tDCS, as compared with sham tDCS, increased the percent signal change associated with foot stimulation relative to rest in the left posterior paracentral lobule. These results indicate that tDCS acutely modulated the cortical responsiveness to controlled foot pressure stimuli in healthy adults. Further study is warranted, in both healthy individuals and patients with sensory impairments, to link tDCS-induced modulation of the cortical response to tactile stimuli with changes in somatosensory perception.

语种英语
所属项目编号11372013 ; 1KL2RR025757-04 ; UL 1RR025758 ; 1K01AG044543-01A1
资助者National Natural Science Foundation of China ; Sidney Baer Foundation ; KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst/The Harvard Clinical and Translational Science Center ; K01 award from the National Institute on Aging ; National Natural Science Foundation of China ; Sidney Baer Foundation ; KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst/The Harvard Clinical and Translational Science Center ; K01 award from the National Institute on Aging
WOS记录号WOS:000358948800007
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65964
专题北京大学第一临床医学院_放射治疗科
作者单位1.Harvard Univ, Sch Med, Boston, MA USA
2.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr BioMed X Res, Beijing 100871, Peoples R China
4.Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA
5.Beth Israel Deaconess Med Ctr, Cognit Neurol Unit, Boston, MA 02215 USA
6.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
7.Hebrew SeniorLife, Inst Aging Res, Boston, MA USA
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GB/T 7714
Wang, Ye,Hao, Ying,Zhou, Junhong,et al. Direct current stimulation over the human sensorimotor cortex modulates the brain&prime;s hemodynamic response to tactile stimulation[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2015,42(3):1933-1940.
APA Wang, Ye.,Hao, Ying.,Zhou, Junhong.,Fried, Peter J..,Wang, Xiaoying.,...&Manor, Brad.(2015).Direct current stimulation over the human sensorimotor cortex modulates the brain′s hemodynamic response to tactile stimulation.EUROPEAN JOURNAL OF NEUROSCIENCE,42(3),1933-1940.
MLA Wang, Ye,et al."Direct current stimulation over the human sensorimotor cortex modulates the brain′s hemodynamic response to tactile stimulation".EUROPEAN JOURNAL OF NEUROSCIENCE 42.3(2015):1933-1940.
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