IR@PKUHSC  > 北京大学第一临床医学院  > 急诊科
学科主题临床医学
Analysis of clinical efficacy of different initial antimicrobial treatment in healthcare associated pneumonia patients in emergency department
Cao Guohui; Chen Xuyan; Wu Sheng
关键词pneumonia health care drug resistance treatment efficacy
刊名CHINESE MEDICAL JOURNAL
2014-05-20
DOI10.3760/cma.j.issn.0366-6999.20132885
127期:10页:1814-1819
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]COMMUNITY-ACQUIRED PNEUMONIA ; HOSPITALIZED-PATIENTS ; ANTIBIOTIC-THERAPY ; RESISTANT PATHOGENS ; OUTCOMES ; EPIDEMIOLOGY ; PREDICTION ; FAILURE ; MULTICENTER ; MORTALITY
英文摘要

Background Community acquired pneumonia (CAP) is one of the most common infectious disease in emergency department. In 2005 the concept of healthcare associated pneumonia (HCAP) was proposed by the ATS/IDSA guidelines. The clinical features and microbiology of HCAP are different from CAP, however, the initial antimicrobial treatment is still controversial. We aimed to compare the clinical efficacy between HCAP patients treated initially with HCAP guideline-concordant antimicrobial agents and those with CAP guideline-concordant antimicrobial agents.

Methods We conducted a retrospective observational study on HCAP patients who were admitted to emergency department between December 2011 and December 2012. Patients were divided into 2 groups according to their different initial antimicrobial treatment. We compared clinical features, distribution of pathogen, severity, days and spending on intravenous antimicrobial, length and charge of hospitalization and clinical outcomes, and meanwhile analyzed the clinical efficacy as well.

Results Of the 125 HCAP patients, 55 patients received CAP guideline-concordant antimicrobial agents and 70 received HCAP agents. The major pathogens were Klebsiella pneumoniae, methicillin-resistant staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Escherichia coli. The 2 groups were similar at baseline, including old age, comorbidities, Pneumonia Severity Index scores, APACHE scores, and length of intravenous antimicrobial use and hospitalization duration, and in-hospital mortality. Overall efficacy rate occurred in 70.0% of HCAP agent patients and 50.9% of CAP agent patients (P=0.029). Antimicrobial charge and total hospital charge for HCAP agent patients were significantly higher than that for CAP agent patients.

Conclusions Initial treatment of HCAP patients in emergency department with HCAP guideline-concordant antimicrobial could increase clinical efficacy rate, as well as antimicrobial charge and total hospital charge, but was not associated with shortening the length of stay, or lowering in-hospital mortality.

语种英语
WOS记录号WOS:000336477100004
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65969
专题北京大学第一临床医学院_急诊科
作者单位Peking Univ, Hosp 1, Dept Emergency Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Cao Guohui,Chen Xuyan,Wu Sheng. Analysis of clinical efficacy of different initial antimicrobial treatment in healthcare associated pneumonia patients in emergency department[J]. CHINESE MEDICAL JOURNAL,2014,127(10):1814-1819.
APA Cao Guohui,Chen Xuyan,&Wu Sheng.(2014).Analysis of clinical efficacy of different initial antimicrobial treatment in healthcare associated pneumonia patients in emergency department.CHINESE MEDICAL JOURNAL,127(10),1814-1819.
MLA Cao Guohui,et al."Analysis of clinical efficacy of different initial antimicrobial treatment in healthcare associated pneumonia patients in emergency department".CHINESE MEDICAL JOURNAL 127.10(2014):1814-1819.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cao Guohui]的文章
[Chen Xuyan]的文章
[Wu Sheng]的文章
百度学术
百度学术中相似的文章
[Cao Guohui]的文章
[Chen Xuyan]的文章
[Wu Sheng]的文章
必应学术
必应学术中相似的文章
[Cao Guohui]的文章
[Chen Xuyan]的文章
[Wu Sheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。