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学科主题: 临床医学
题名:
Expression of metallothionein-I and II in skin ageing and its association with skin proliferation
作者: Ma, C.; Li, L. -F.; Chen, X.
刊名: BRITISH JOURNAL OF DERMATOLOGY
发表日期: 2011-03-01
DOI: 10.1111/j.1365-2133.2010.10117.x
卷: 164, 期:3, 页:479-482
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: ZINC ; INDUCTION ; EXPOSURE ; MARKERS
英文摘要:

P>Background

Metallothioneins (MT) are important antioxidants involved in the ageing process of many tissues and organs. To our knowledge, the role of MT in skin ageing has not been reported.

Objectives

To investigate the expression of MT in ageing skin.

Methods

The protein levels of MT-I and MT-II in sun-exposed and sun-protected skin specimens obtained from healthy individuals were detected by immunohistochemistry using tissue microarray and expressed as average integrated optical density (AIOD). Proliferating cell nuclear antigen (PCNA) and Ki-67 protein levels in these specimens were also detected to study the possible link between the proliferation of keratinocytes and expression of MT.

Results

The protein levels of MT-I and MT-II decreased significantly with increasing age of sun-exposed and sun-protected skin (r = -0 center dot 73 and -0 center dot 98, respectively, P < 0 center dot 01) but was more prominent in sun-exposed skin. In sex- and age-matched specimens, the intensity of MT-I and MT-II in sun-exposed skin was much lower than in sun-protected skin (9 center dot 46 +/- 2 center dot 39 vs. 22 center dot 25 +/- 8 center dot 04, mean +/- SD of AIOD, P < 0 center dot 01, Student′s t-test). The expression of PCNA and Ki-67 showed the same trend.

Conclusions

The expression of MT-I and MT-II declined with the decrease of keratinocyte proliferation in the process of skin ageing, and this decline was more significant in sun-exposed skin. Whether MT-I and MT-II supplementation could inhibit skin ageing, especially photoageing, merits further study.

语种: 英语
项目资助者: Ministry of Education, China
WOS记录号: WOS:000288076200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65972
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: Peking Univ, Dept Dermatol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Ma, C.,Li, L. -F.,Chen, X.. Expression of metallothionein-I and II in skin ageing and its association with skin proliferation[J]. BRITISH JOURNAL OF DERMATOLOGY,2011,164(3):479-482.
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