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Amplitude of Low-Frequency Oscillations in First-Episode, Treatment-Naive Patients with Major Depressive Disorder: A Resting-State Functional MRI Study
Wang, Li1,2; Dai, Wenji1,2; Su, Yunai1,2; Wang, Gang3; Tan, Yunlong4; Jin, Zhen5; Zeng, Yawei5; Yu, Xin1,2; Chen, Wei6; Wang, Xiaodong7; Si, Tianmei1,2
刊名PLOS ONE
2012-10-31
DOI10.1371/journal.pone.0048658
7期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; DEFAULT MODE NETWORK ; MAGNETIC-RESONANCE ; REGIONAL HOMOGENEITY ; UNIPOLAR DEPRESSION ; TREATMENT-RESISTANT ; PREFRONTAL CORTEX ; COGNITIVE MODEL ; NEURAL ACTIVITY ; BRAIN ACTIVITY
英文摘要

Background: Resting-state fMRI is a novel approach to measure spontaneous brain activity in patients with major depressive disorder (MDD). Although most resting-state fMRI studies have focused on the examination of temporal correlations between low-frequency oscillations (LFOs), few studies have explored the amplitude of these LFOs in MDD. In this study, we applied the approaches of amplitude of low-frequency fluctuation (ALFF) and fractional ALFF to examine the amplitude of LFOs in MDD.

Methodology/Principal Findings: A total of 36 subjects, 18 first-episode, treatment-naive patients with MDD matched with 18 healthy controls (HCs) completed the fMRI scans. Compared with HCs, MDD patients showed increased ALFF in the right fusiform gyrus and the right anterior and posterior lobes of the cerebellum but decreased ALFF in the left inferior temporal gyrus, bilateral inferior parietal lobule, and right lingual gyrus. The fALFF in patients was significantly increased in the right precentral gyrus, right inferior temporal gyrus, bilateral fusiform gyrus, and bilateral anterior and posterior lobes of the cerebellum but was decreased in the left dorsolateral prefrontal cortex, bilateral medial orbitofrontal cortex, bilateral middle temporal gyrus, left inferior temporal gyrus, and right inferior parietal lobule. After taking gray matter (GM) volume as a covariate, the results still remained.

Conclusions/Significance: These findings indicate that MDD patients have altered LFO amplitude in a number of regions distributed over the frontal, temporal, parietal, and occipital cortices and the cerebellum. These aberrant regions may be related to the disturbances of multiple emotion-and cognition-related networks observed in MDD and the apparent heterogeneity in depressive symptom domains. Such brain functional alteration of MDD may contribute to further understanding of MDD-related network imbalances demonstrated in previous fMRI studies.

语种英语
WOS记录号WOS:000310600500192
项目编号2009-2026
资助机构Capital Foundation of Medicine Research and Development
引用统计
被引频次:55[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65975
专题北京大学精神卫生研究所
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing, Peoples R China
3.Peoples Liberat Army, Hosp 306, Dept Radiol, Beijing, Peoples R China
4.Max Planck Inst Psychiat, D-80804 Munich, Germany
5.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
6.Chinese Minist Hlth, Key Lab Med Neurobiol, Hangzhou, Zhejiang, Peoples R China
7.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Li,Dai, Wenji,Su, Yunai,et al. Amplitude of Low-Frequency Oscillations in First-Episode, Treatment-Naive Patients with Major Depressive Disorder: A Resting-State Functional MRI Study[J]. PLOS ONE,2012,7(10).
APA Wang, Li.,Dai, Wenji.,Su, Yunai.,Wang, Gang.,Tan, Yunlong.,...&Si, Tianmei.(2012).Amplitude of Low-Frequency Oscillations in First-Episode, Treatment-Naive Patients with Major Depressive Disorder: A Resting-State Functional MRI Study.PLOS ONE,7(10).
MLA Wang, Li,et al."Amplitude of Low-Frequency Oscillations in First-Episode, Treatment-Naive Patients with Major Depressive Disorder: A Resting-State Functional MRI Study".PLOS ONE 7.10(2012).
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