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学科主题: 公共卫生
题名:
Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression
作者: Qi, Yitao; Tu, Yiding; Yang, Di; Chen, Qian; Xiao, Jun; Chen, Yiqiang; Fu, Juanling; Xiao, Xilong; Zhou, Zongcan
刊名: JOURNAL OF CELLULAR PHYSIOLOGY
发表日期: 2007
DOI: 10.1002/jcp.20816
卷: 210, 期:1, 页:63-71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Physiology
研究领域[WOS]: Cell Biology ; Physiology
关键词[WOS]: E CDK2 KINASE ; DEPENDENT KINASES ; PROTEIN-SYNTHESIS ; GENE-EXPRESSION ; RAT FIBROBLASTS ; GROWTH ; ACTIVATION ; REPRESSION ; PROLIFERATION ; TRANSCRIPTION
英文摘要:

The proto-oncogene c-myc is a key player in cell-cycle regulation and is deregulated in a broad range of human cancers and cell proliferation disorders. Here we reported that overexpression of c-myc in human embryonic lung fibroblasts (HEL) that have low endogenous c-myc enriched S phase cells with increased expression of cyclin D3, E, A, Cdk2, and Cdk4, and decreased expression of p21 and p27. To the opposite, using RNAi to downregulate c-myc expression in A549 cells that have high endogenous c-myc enriched G1 phase cells with decreased expression of cyclin D3, E, A, Cdk2, Cdk4, and increased expression of p21 and p27. We found that cyclin A expression was the most susceptive to changes in c-myc levels and essential in c-myc-modulated cell cycle pathway via co-transfection, however, cyclin D1 showed no change between treated and control groups in either HEL or A549 cells. Our results indicated that upregulation of c-myc expression promotes cell cycling in HEL cells, whereas downregulation of c-myc expression causes G1 phase arrest in A549 cells, and the c-myc-mediated cell-cycle regulation pathway was dependent on cyclin A and involved cyclin D3, E, Cdk2, Cdk4, p21, and p27, but not cyclin D1.

语种: 英语
WOS记录号: WOS:000242568200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65982
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.China Agr Univ, Coll Vet Med, Dept Pharmacol & Toxicol, Beijing 100094, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing, Peoples R China

Recommended Citation:
Qi, Yitao,Tu, Yiding,Yang, Di,et al. Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2007,210(1):63-71.
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