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Triterpene saponins from the roots of Ilex pubescens
Zhou, Yuan1; Zeng, Kewu1; Zhang, Jiayu3; Li, Ning1; Chai, Xingyun2; Jiang, Yong1; Tu, Pengfei1,2
关键词Ilex pubescens Aquifoliaceae Ilexpublesnins N-R Triterpene saponin 20-hydroxyursolic acid Cytotoxic
刊名FITOTERAPIA
2014-09-01
DOI10.1016/j.fitote.2014.05.020
97页:98-104
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]NMR SPECTROSCOPIC DATA ; CHEMICAL-CONSTITUENTS ; COMPLETE ASSIGNMENTS ; LEAVES ; PERNYI ; HAINANENSIS ; GLYCOSIDES ; KUDINGCHA ; H-1
英文摘要

Five new triterpene saponins, Ilexpublesnins N-R (1-5), along with seven known analogs were isolated from the root of Hex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Ilexpublesnin N (1) possessed a rare 20-hydroxyursolic acid scaffold from natural resource. These compounds were evaluated in vitro for their cytotoxic effects on human cancer cell lines HepG2, HLE, BEL7402, BEL7403, BEL7405, MCF-7, HeLa. Among them, only compounds 5 and 10 showed cytotoxic potentiality against BEl-7403 and HEL cell lines [inhibition (%): 35.38 and 45.12, respectively]. (c) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000341346400013
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65994
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
3.Beijing Univ Chinese Med, Ctr Sci Expt, Beijing 100029, Peoples R China
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GB/T 7714
Zhou, Yuan,Zeng, Kewu,Zhang, Jiayu,et al. Triterpene saponins from the roots of Ilex pubescens[J]. FITOTERAPIA,2014,97:98-104.
APA Zhou, Yuan.,Zeng, Kewu.,Zhang, Jiayu.,Li, Ning.,Chai, Xingyun.,...&Tu, Pengfei.(2014).Triterpene saponins from the roots of Ilex pubescens.FITOTERAPIA,97,98-104.
MLA Zhou, Yuan,et al."Triterpene saponins from the roots of Ilex pubescens".FITOTERAPIA 97(2014):98-104.
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