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学科主题: 药学
题名:
Triterpene saponins from the roots of Ilex pubescens
作者: Zhou, Yuan1; Zeng, Kewu1; Zhang, Jiayu3; Li, Ning1; Chai, Xingyun2; Jiang, Yong1; Tu, Pengfei1,2
关键词: Ilex pubescens ; Aquifoliaceae ; Ilexpublesnins N-R ; Triterpene saponin ; 20-hydroxyursolic acid ; Cytotoxic
刊名: FITOTERAPIA
发表日期: 2014-09-01
DOI: 10.1016/j.fitote.2014.05.020
卷: 97, 页:98-104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NMR SPECTROSCOPIC DATA ; CHEMICAL-CONSTITUENTS ; COMPLETE ASSIGNMENTS ; LEAVES ; PERNYI ; HAINANENSIS ; GLYCOSIDES ; KUDINGCHA ; H-1
英文摘要:

Five new triterpene saponins, Ilexpublesnins N-R (1-5), along with seven known analogs were isolated from the root of Hex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Ilexpublesnin N (1) possessed a rare 20-hydroxyursolic acid scaffold from natural resource. These compounds were evaluated in vitro for their cytotoxic effects on human cancer cell lines HepG2, HLE, BEL7402, BEL7403, BEL7405, MCF-7, HeLa. Among them, only compounds 5 and 10 showed cytotoxic potentiality against BEl-7403 and HEL cell lines [inhibition (%): 35.38 and 45.12, respectively]. (c) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30672608 ; 2009ZX09311-004
项目资助者: National Natural Science Foundation of China ; Scientific and Technological Major Special Project for &prime ; Significant Creation of New Drugs&prime
WOS记录号: WOS:000341346400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65994
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
3.Beijing Univ Chinese Med, Ctr Sci Expt, Beijing 100029, Peoples R China

Recommended Citation:
Zhou, Yuan,Zeng, Kewu,Zhang, Jiayu,et al. Triterpene saponins from the roots of Ilex pubescens[J]. FITOTERAPIA,2014,97:98-104.
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