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学科主题: 临床医学
题名:
HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition
作者: Xu, Xiaojie1; Jiang, Chengying2,3,4; Wang, Shibin5; Tai, Yanhong2; Wang, Tao1; Kang, Lei6; Fan, Zhongyi2; Li, Shuyue1; Li, Ling1; Fu, Jing1; Liu, Jiahong1; Ji, Quanbo1; Wang, Xuan1; Wei, Lixin2; Ye, Qinong1
关键词: hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein ; cell cycle ; liver cancer ; cell growth
刊名: IUBMB LIFE
发表日期: 2013-10-01
DOI: 10.1002/iub.1202
卷: 65, 期:10, 页:873-882
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: INTERACTING PROTEIN HPIP ; HEPATOCELLULAR-CARCINOMA ; CYCLIN B1 ; PROGNOSTIC IMPLICATIONS ; GENE-EXPRESSION ; APOPTOSIS ; P53 ; BIOMARKERS ; LEUKEMIA ; RECEPTOR
英文摘要:

Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) has been shown to play a role in cancer development and progression. However, the detailed role of HPIP in cancer cell growth and the exact mechanism by which HPIP regulates cancer cell proliferation remains unclear. Here, we report that HPIP is overexpressed in most of 328 liver cancer patients and regulates hepatoma cell proliferation through G2/M checkpoint activation. HPIP increased anchorage-dependent and -independent growth of human liver cancer cell lines. The amino acid region 531-631 of HPIP was important for its modulation of liver cancer cell growth. The increased effects of HPIP on liver cancer cell proliferation were associated with activation of the G2/M cell-cycle concomitant with a marked increase of cyclin B1 and the inhibition of the negative G2/M phase regulator GADD45. HPIP knockdown dramatically suppressed the growth of HepG2 liver cancer cells in nude mice. These data highlight the important role of HPIP in liver cancer cell growth and suggest that HPIP may be a good target for liver cancer therapy. (c) 2013 IUBMB Life, 65(10):873-882, 2013

语种: 英语
所属项目编号: 2011CB504202 ; 2012CB945100 ; 31100604 ; 81272913 ; 81072173
项目资助者: Major State Basic Research Development Program ; National Natural Science Foundation
WOS记录号: WOS:000325027200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65996
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Tianjin Med Univ Canc Inst & Hosp, Res Lab, Tianjin, Peoples R China
2.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
4.Tianjin Med Univ Canc Inst & Hosp, Dept Breast Canc Pathol, Tianjin, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Gen Surg, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Xiaojie,Jiang, Chengying,Wang, Shibin,et al. HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition[J]. IUBMB LIFE,2013,65(10):873-882.
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