IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科
学科主题临床医学
HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition
Xu, Xiaojie1; Jiang, Chengying2,3,4; Wang, Shibin5; Tai, Yanhong2; Wang, Tao1; Kang, Lei6; Fan, Zhongyi2; Li, Shuyue1; Li, Ling1; Fu, Jing1; Liu, Jiahong1; Ji, Quanbo1; Wang, Xuan1; Wei, Lixin2; Ye, Qinong1
关键词hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein cell cycle liver cancer cell growth
刊名IUBMB LIFE
2013-10-01
DOI10.1002/iub.1202
65期:10页:873-882
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]INTERACTING PROTEIN HPIP ; HEPATOCELLULAR-CARCINOMA ; CYCLIN B1 ; PROGNOSTIC IMPLICATIONS ; GENE-EXPRESSION ; APOPTOSIS ; P53 ; BIOMARKERS ; LEUKEMIA ; RECEPTOR
英文摘要

Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) has been shown to play a role in cancer development and progression. However, the detailed role of HPIP in cancer cell growth and the exact mechanism by which HPIP regulates cancer cell proliferation remains unclear. Here, we report that HPIP is overexpressed in most of 328 liver cancer patients and regulates hepatoma cell proliferation through G2/M checkpoint activation. HPIP increased anchorage-dependent and -independent growth of human liver cancer cell lines. The amino acid region 531-631 of HPIP was important for its modulation of liver cancer cell growth. The increased effects of HPIP on liver cancer cell proliferation were associated with activation of the G2/M cell-cycle concomitant with a marked increase of cyclin B1 and the inhibition of the negative G2/M phase regulator GADD45. HPIP knockdown dramatically suppressed the growth of HepG2 liver cancer cells in nude mice. These data highlight the important role of HPIP in liver cancer cell growth and suggest that HPIP may be a good target for liver cancer therapy. (c) 2013 IUBMB Life, 65(10):873-882, 2013

语种英语
WOS记录号WOS:000325027200008
项目编号2011CB504202 ; 2012CB945100 ; 31100604 ; 81272913 ; 81072173
资助机构Major State Basic Research Development Program ; National Natural Science Foundation
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65996
专题北京大学第一临床医学院_核医学科
作者单位1.Tianjin Med Univ Canc Inst & Hosp, Res Lab, Tianjin, Peoples R China
2.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
4.Tianjin Med Univ Canc Inst & Hosp, Dept Breast Canc Pathol, Tianjin, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Gen Surg, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Xiaojie,Jiang, Chengying,Wang, Shibin,et al. HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition[J]. IUBMB LIFE,2013,65(10):873-882.
APA Xu, Xiaojie.,Jiang, Chengying.,Wang, Shibin.,Tai, Yanhong.,Wang, Tao.,...&Ye, Qinong.(2013).HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition.IUBMB LIFE,65(10),873-882.
MLA Xu, Xiaojie,et al."HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition".IUBMB LIFE 65.10(2013):873-882.
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