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学科主题: 临床医学
题名:
Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China
作者: Zhou, Jianfang1,2; Qian, Chuanyun3,4; Zhao, Mingyan5; Yu, Xiangyou6; Kang, Yan7; Ma, Xiaochun8; Ai, Yuhang9; Xu, Yuan10; Liu, Dexin11; An, Youzhong12; Wu, Dawei13; Sun, Renhua14; Li, Shusheng15; Hu, Zhenjie16; Cao, Xiangyuan17; Zhou, Fachun18; Jiang, Li19; Lin, Jiandong20; Mao, Enqiang21; Qin, Tiehe22; He, Zhenyang23; Zhou, Lihua24; Du, Bin1,2; CCCCTG
刊名: PLOS ONE
发表日期: 2014-09-16
DOI: 10.1371/journal.pone.0107181
卷: 9, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: 10 UNIVERSITY HOSPITALS ; CRITICALLY-ILL PATIENTS ; CONSENSUS CONFERENCE ; NORTHERN-IRELAND ; RISK-FACTORS ; OF-LIFE ; MULTICENTER ; MORTALITY ; DEFINITIONS ; FAILURE
英文摘要:

Introduction: Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality.

Methods: We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included.

Results: A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027-1.109), presence of ARDS (OR, 2.676; 95% CI, 1.691-4.235), bloodstream infection (OR, 2.520; 95% CI, 1.142-5.564) and comorbidity of cancer (OR, 2.246; 95% CI, 1.141-4.420) were significantly associated with mortality.

Conclusions: Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.

语种: 英语
所属项目编号: Z131107002213112
项目资助者: Capital Clinical Application Research grant from the Science and Technology Commission of Beijing
WOS记录号: WOS:000344317700034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65998
Appears in Collections:北京大学第二临床医学院_重症医学科_期刊论文

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作者单位: 1.Beijing Union Med Coll Hosp, Peking Union Med Coll, Med ICU, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Beijing 100730, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Emergency Med, Kunming, Peoples R China
4.Kunming Med Univ, Affiliated Hosp 1, Med ICU, Kunming, Peoples R China
5.Harbin Med Univ, Dept Crit Care Med, Affiliated Hosp 1, Harbin, Peoples R China
6.Xinjiang Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Urumqi, Peoples R China
7.Sichuan Univ, Dept Crit Care Med, West China Hosp, Chengdu 610064, Peoples R China
8.China Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Shenyang, Peoples R China
9.Cent S Univ, Xiangya Hosp, Dept Crit Care Med, Changsha, Hunan, Peoples R China
10.Capital Med Univ, Beijing Tongren Hosp, Dept Crit Care Med, Beijing, Peoples R China
11.Jilin Univ, Dept Crit Care Med, Hosp 2, Changchun 130023, Peoples R China
12.Peking Univ, Peoples Hosp, Dept Crit Care Med, Beijing 100871, Peoples R China
13.Shandong Univ, Qilu Hosp, Dept Crit Care Med, Jinan 250100, Peoples R China
14.Zhejiang Prov Peoples Hosp, Dept Crit Care Med, Hangzhou, Zhejiang, Peoples R China
15.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Crit Care Med, Wuhan 430074, Peoples R China
16.Hebei Med Univ, Dept Crit Care Med, Hosp 4, Shijiazhuang, Peoples R China
17.Ningxia Med Univ, Gen Hosp, Dept Crit Care Med, Yinchuan, Peoples R China
18.Chongqing Med Univ, Affiliated Hosp 1, Dept Emergency & Intens Care Med, Chongqing, Peoples R China
19.Capital Med Univ, Fuxing Hosp, Dept Crit Care Med, Beijing, Peoples R China
20.Fujian Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Fuzhou, Peoples R China
21.Shanghai Jiao Tong Univ, Ruijin Hosp, Emergency ICU, Shanghai 200030, Peoples R China
22.Guangdong Gen Hosp, Dept Crit Care Med, Guangzhou, Guangdong, Peoples R China
23.Inner Mongolia Med Univ, Affiliated Hosp, Dept Crit Care Med, Hohhot, Peoples R China
24.Hainan Prov Peoples Hosp, Dept Crit Care Med, Haikou, Peoples R China

Recommended Citation:
Zhou, Jianfang,Qian, Chuanyun,Zhao, Mingyan,et al. Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China[J]. PLOS ONE,2014,9(9).
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