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IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Percutaneous Ultrasonography-Guided Permanent Iodine-125 Implantation as Salvage Therapy for Recurrent Head and Neck Carcimonas
作者: Jiang, Ping1; Jiang, Yuliang1; Wang, Jun-Jie1; Meng, Na1; Ran, Weiqiang2; Qu, Ang1; Yang, Ruijie1
关键词: head and neck ; (125)I seed implantation ; outcome ; recurrent carcinoma ; ultrasonography
刊名: CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
发表日期: 2011-12-01
DOI: 10.1089/cbr.2010.0844
卷: 26, 期:6, 页:753-757
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: RADIATION-THERAPY ; SEED IMPLANTATION ; EUROPEAN-ORGANIZATION ; I125 IMPLANTS ; CANCER ; CARCINOMA ; REIRRADIATION ; BRACHYTHERAPY ; RADIOTHERAPY ; ADJUVANT
英文摘要:

Twenty-nine (29) patients with recurrent head and neck carcinomas underwent (125)I seed permanent implantation under ultrasonography guidance and the feasibility and efficacy of (125)I seed implantation were assessed. The postplan evaluation showed that the actuarial D90 of (125)I seeds ranged from 90 to 160 Gy (median, 130 Gy). The activity of each (125)I seed ranged from 0.35 to 0.8 mCi (median, 0.6 mCi). The total number of sources implanted ranged from 3 to 61 (median, 22). The follow-up ranged from 3 to 40 months (median, 8 months). The 1-, 2-, and 3-year local control rates were 53.1%, 34.8%, and 17.4%, respectively, with a median local control of 16 months (95% confidence interval, 5.8-26.1). The 1-, 2-, and 3-year survival rates were 54.1%, 27.5%, and 27.5%, respectively (median, 13 months; 95% confidence interval, 6.0-19.9). Of the 25 patients, 5 (17.2%) died of local recurrence and 7 (24.1%) died of metastases; 2 patients showed recurrences at 3 and 8 months after seed implantation and subsequently died of pneumonia. One (1) patient died of heart disease. One (1) developed ulceration with tumor progression. Blood vessel damage and neuropathy were not observed. Percutaneous ultrasound-guided (125)I seed implantation is a feasible, safe salvage for patients with recurrent carcinomas of the head and neck.

语种: 英语
所属项目编号: 2009-2024
项目资助者: Foundation of Capital Medical Development and Research
WOS记录号: WOS:000298144600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66011
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Ultrasound, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Ping,Jiang, Yuliang,Wang, Jun-Jie,et al. Percutaneous Ultrasonography-Guided Permanent Iodine-125 Implantation as Salvage Therapy for Recurrent Head and Neck Carcimonas[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2011,26(6):753-757.
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