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Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine
Zhou, JL; Liang, JH; Zheng, JW; Li, CL
关键词methamphetamine neurotoxicity apoptosis nerve growth factor
刊名TOXICOLOGY LETTERS
2004-04-21
DOI10.1016/j.toxlet.2004.01.007
150期:2页:221-227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]FREE-RADICALS ; NEURAL CELLS ; APOPTOSIS ; DOPAMINE ; RECEPTOR ; NEURONS ; EXPRESSION ; INDUCTION ; TOXICITY ; DAMAGE
英文摘要

It is well known that methamphetamine is a neurotoxic drug of abuse to cause cell death both in vitro and in vivo. In this study, the protective effect of nerve growth factor on methamphetamine-induced neurotoxicity was examined in R2 cells. Treatment of R2 cells with methamphetamine for 48 It induced apoptotic-like death as determined by cell viability assay, DNA fragmentation on agarose gel and flow cytometric analysis. Co-treatment of R2 cells with nerve growth factor (10-1000 U/ml) in the presence of methamphetamine increased cell viability, decreased the intensity of methamphetamine-induced DNA fragmentation and reduced the number of apoptotic cells with flow cytometry. These results indicate that nerve growth factor may be useful for the treatment of methamphetamine users. (C)d 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000221131800009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66012
专题中国药物依赖性研究所
作者单位1.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, JL,Liang, JH,Zheng, JW,et al. Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine[J]. TOXICOLOGY LETTERS,2004,150(2):221-227.
APA Zhou, JL,Liang, JH,Zheng, JW,&Li, CL.(2004).Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine.TOXICOLOGY LETTERS,150(2),221-227.
MLA Zhou, JL,et al."Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine".TOXICOLOGY LETTERS 150.2(2004):221-227.
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