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学科主题药学
Population pharmacokinetics study of azithromycin oral formulations using NONMEM
Zhang, X-Y.3; Wang, Y-R.1; Zhang, Q.1,2; Lu, W.1,2
关键词azithromycin population pharmacokinetics NONMEM
刊名INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
2010-10-01
48期:10页:662-669
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

Objective: A population pharmacokinetic study of orally dosed azithromycin was conducted in order to determine if the antibiotic usage in clinical practice is reasonable and individualized. Method: A nonlinear mixed effect model with various oral azithromycin formulations was constructed using the NONMEM program. Based on a dataset of 160 healthy volunteers, the pharmacokinetic parameters and the relationship between the inter-individual effects and fixed effects were estimated. Result: A two compartment model with first-order absorption and elimination was established. The values for Cl(1)/F, Cl(2)/F, V(1)/F, V(2)/F and Ka were 121 ml/h, 282 ml/h, 1,939 ml, 5,650 ml and 1.05 h(-1), respectively. The results provided evidence that the body weight affects the Cl(1)/F and Cl(2)/F and age affects the V(1)/F. Conclusion: A nonlinear mixed effect model for oral azithromycin formulations was developed for a Chinese healthy population.

语种英语
WOS记录号WOS:000284131200004
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66016
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Shenyang Pharmaceut Univ, Coll Pharmaceut, Shenyang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, X-Y.,Wang, Y-R.,Zhang, Q.,et al. Population pharmacokinetics study of azithromycin oral formulations using NONMEM[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2010,48(10):662-669.
APA Zhang, X-Y.,Wang, Y-R.,Zhang, Q.,&Lu, W..(2010).Population pharmacokinetics study of azithromycin oral formulations using NONMEM.INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,48(10),662-669.
MLA Zhang, X-Y.,et al."Population pharmacokinetics study of azithromycin oral formulations using NONMEM".INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 48.10(2010):662-669.
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